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Aristolochic acid A sodium

(Synonyms: Aristolochic acid I sodium; TR 1736 sodium)
11 Cited Publications
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Based on 11 publication(s) in Google Scholar

Aristolochic acid A (Aristolochic acid I) sodium is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A sodium significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A sodium reduces BLCAP gene expression in human cell lines.

For research use only. We do not sell to patients.

  • Purity: 99.93%
  • CAS No.: 10190-99-5
  • Formula: C17H10NNaO7
  • Molecular Weight:363.25
  • Storage:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Aristolochic acid A sodium Chemical Structure
    Aristolochic acid A sodium Chemical Structure
  • Experimental Validation Results for Aristolochic acid A sodium
  • Experimental Validation Results for Aristolochic acid A sodium
  • Experimental Validation Results for Aristolochic acid A sodium
  • Experimental Validation Results for Aristolochic acid A sodium
  • Experimental Validation Results for Aristolochic acid A sodium
  • Experimental Validation Results for Aristolochic acid A sodium
  • Experimental Validation Results for Aristolochic acid A sodium
CAS No.: 10190-99-5
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  • Aristolochic acid A sodium Chemical Structure
    Aristolochic acid A sodium Chemical Structure
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    Aristolochic acid A sodium purchased from MedChemExpress. Usage Cited in: Nature. 2024 Jul;631(8020):459-466. [Abstract]

    Customer Validation
     FLIPR Ca2+ assay responses in wild-type (WT) TAS2R14 and mutants in pockets 1, 2 and 3, following Aristolochic acid A (150 μM) stimulation. The negative logarithmic half-maximal effective concentration (pEC50) and the maximum response (Emax) values were calculated from the concentration–response curves.

  • 1/16

    Aristolochic acid A sodium purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day). Body weight of mice in Control, AAI-4w, and AAI-8w groups.

  • 1/16

    Aristolochic acid A sodium purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day, 4 or 8 weeks). H&E staining showed pathological changes of mice livers after AAI treatment, scale bar = 100 μm.

  • 1/16

    Aristolochic acid A sodium purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day, 4 or 8 weeks). Liver/body weight ratio after AAI treatment (n = 5, ***P < 0.001, ns = not significant). Effects of AAI on the levels of serum ALT and AST in the indicated groups (n = 5, *P < 0.05, **P < 0.01, ns = not significant).

  • 1/16

    Aristolochic acid A sodium purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day, 4 or 8 weeks). IF staining of p-STAT3 (red) in the three groups, and the nuclei were stained by Hoechst (blue), scale bar = 50 µm.

  • 1/16

    Aristolochic acid A sodium purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day, 4 or 8 weeks). IF staining of Bcl-2 (green) and Bax (Red) to detect endothelial cell apoptosis in the three groups, the nucleus was labelled by Hoechst (blue), scale bar = 40 µm.

  • 1/16

    Aristolochic acid A sodium purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day, 4 or 8 weeks). Western blot was used to detect the expression of apoptotic signaling pathway-related markers cleaved-caspase 3, Bax, and Bcl-2 in liver tissues after AAI treatment.

  • Aristolochic acid A sodium