Cholestenone-13C2
Based on 1 Customer Validation
Cholestenone-13C2 is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells.
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- Reinheit: 99.06%
- CAS. Nr.: 82938-09-8
- Formel: C2513C2H44O
- Molecular Weight:386.62
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 82938-09-8
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Unlabeled Cas 601-57-0
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Appearance Solid
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Molecular Weight 386.62
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Formel C2513C2H44O
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Color White to off-white
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SMILES
CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=[13CH][13C](CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
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Synonyms
4-Cholesten-3-one-13C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
Ethanol : 50 mg/mL (129.33 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Rosenheim O, et al. The mechanism of coprosterol formation in vivo: 1. Cholestenone as an intermediate. Biochem J. 1943 Oct;37(4):513-4. [Content Brief]
[3]. Neuvonen M, et, al. Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. PLoS One. 2014 Aug 26;9(8):e103743. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.5865 mL | 12.9326 mL | 25.8652 mL | 64.6630 mL |
| 5 mM | 0.5173 mL | 2.5865 mL | 5.1730 mL | 12.9326 mL | |
| 10 mM | 0.2587 mL | 1.2933 mL | 2.5865 mL | 6.4663 mL | |
| 15 mM | 0.1724 mL | 0.8622 mL | 1.7243 mL | 4.3109 mL | |
| 20 mM | 0.1293 mL | 0.6466 mL | 1.2933 mL | 3.2331 mL | |
| 25 mM | 0.1035 mL | 0.5173 mL | 1.0346 mL | 2.5865 mL | |
| 30 mM | 0.0862 mL | 0.4311 mL | 0.8622 mL | 2.1554 mL | |
| 40 mM | 0.0647 mL | 0.3233 mL | 0.6466 mL | 1.6166 mL | |
| 50 mM | 0.0517 mL | 0.2587 mL | 0.5173 mL | 1.2933 mL | |
| 60 mM | 0.0431 mL | 0.2155 mL | 0.4311 mL | 1.0777 mL | |
| 80 mM | 0.0323 mL | 0.1617 mL | 0.3233 mL | 0.8083 mL | |
| 100 mM | 0.0259 mL | 0.1293 mL | 0.2587 mL | 0.6466 mL |
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