Elabela(19-32)
Based on 6 publication(s) in Google Scholar
Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart.
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- Reinheit: 98.18%
- CAS. Nr.: 1886973-05-2
- Formel: C75H119N25O17S2
- Molecular Weight:1707.03
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Speicherung:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Elabela(19-32)
More- Nat Commun. 2025 Jul 21;16(1):6682. [Abstract]
- Mol Med. 2024 Nov 20;30(1):223. [Abstract]
- Free Radic Biol Med. 2022 Mar:181:130-142. [Abstract]
- Int Immunopharmacol. 2025 Dec 26:170:116068. [Abstract]
- Cell Stress Chaperones. 2023 Jan;28(1):91-103. [Abstract]
- J Cardiovasc Transl Res. 2022 Jun;15(3):535-547. [Abstract]
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Biologische Aktivität
IC50: 8.6 nM (Gαi1) and 166 nM (β-arrestin-2)[1]
Elabela(19-32) (analogue 3) has a Ki of 0.93 nM for binding of radioligand apelin-13[Glp65, Nle75, Tyr77][125I][1].
Elabela(19-32) has an EC50 of 36 nM in HEK293 cells transiently expressing the HA-hAPJ receptor. Elabela(19-32) is slightly less potent than apelin-13 and ELA to elicit receptor internalization[1].
Elabela(19-32) (0.001 to 0.3 nM) has an EC50 of 1.5 pM in inducing changes in left ventricular developed pressure (LVDP) on the Langendorff perfused isolated rat heart[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1886973-05-2
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Appearance Solid
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Molecular Weight 1707.03
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Formel C75H119N25O17S2
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Color White to off-white
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Sequence
{Glp}-Arg-Arg-Cys-Met-Pro-Leu-His-Ser-Arg-Val-Pro-Phe-Pro
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Sequence Shortening
{Glp}-RRCMPLHSRVPFP
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Nat Commun
In vivo measurement of an Apelin gradient with a genetically encoded APLNR conformation biosensor. [Abstract]2025 Jul 21;16(1):6682. PMID: 40691309 -
Mol Med
Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling. [Abstract]2024 Nov 20;30(1):223. PMID: 39567863 -
Free Radic Biol Med
Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling. [Abstract]2022 Mar:181:130-142. PMID: 35122997 -
Int Immunopharmacol
Elabela APJ Axis attenuates type II diabetes osteoporosis by enhancing the coupling of H-type angiogenesis and osteogenesis. [Abstract]2025 Dec 26:170:116068. PMID: 41455365 -
Cell Stress Chaperones
Elabela blunts doxorubicin-induced oxidative stress and ferroptosis in rat aortic adventitial fibroblasts by activating the KLF15/GPX4 signaling. [Abstract]2023 Jan;28(1):91-103. PMID: 36510036 -
J Cardiovasc Transl Res
MicroRNA-122-5p Aggravates Angiotensin II-Mediated Myocardial Fibrosis and Dysfunction in Hypertensive Rats by Regulating the Elabela/Apelin-APJ and ACE2-GDF15-Porimin Signaling. [Abstract]2022 Jun;15(3):535-547. PMID: 35174434
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (58.58 mM; Need ultrasonic)
DMSO : 25 mg/mL (14.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (29.29 mM); Clear solution; Need ultrasonic
Reinheit & Dokumentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.5858 mL | 2.9291 mL | 5.8581 mL | 14.6453 mL |
| 5 mM | 0.1172 mL | 0.5858 mL | 1.1716 mL | 2.9291 mL | |
| 10 mM | 0.0586 mL | 0.2929 mL | 0.5858 mL | 1.4645 mL | |
| H2O | 15 mM | 0.0391 mL | 0.1953 mL | 0.3905 mL | 0.9764 mL |
| 20 mM | 0.0293 mL | 0.1465 mL | 0.2929 mL | 0.7323 mL | |
| 25 mM | 0.0234 mL | 0.1172 mL | 0.2343 mL | 0.5858 mL | |
| 30 mM | 0.0195 mL | 0.0976 mL | 0.1953 mL | 0.4882 mL | |
| 40 mM | 0.0146 mL | 0.0732 mL | 0.1465 mL | 0.3661 mL | |
| 50 mM | 0.0117 mL | 0.0586 mL | 0.1172 mL | 0.2929 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Elabela(19-32) Related Classifications
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