Brdt - bromodomain, testis-specific Gene

Also Known as Brd6; Fsrg3; 7420412D09Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 114642

About Brdt

Chromosome 5: 107,479,025-107,534,924 forward strand.GRCm39:CM000998.3

This gene has 4 transcripts (splice variants), 148 orthologues, 11 paralogues and is associated with 18 phenotypes. Biased expression in testis adult (RPKM 12.3), cortex adult (RPKM 1.6) and 6 other tissues.

Summary

The protein encoded by this gene belongs to the BET protein family. BET proteins have two N-terminal bromodomains and one C-terminal extraterminal domain (ET domain). BET proteins regulate chromatin reorganization via binding to acetylated histones. This gene is thought to play a role in the transcriptional regulation of spermatogenesis. Although referred to as testis-specific bromodomain (Brdt) protein, RT-PCR indicates that this gene is expressed in both mouse oocytes and testes. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]

Brdt Products (2)

mRNA	Protein	Name
NM_054054.2	NP_473395.2	bromodomain testis-specific protein isoform A
NM_001079873.1	NP_001073342.1	bromodomain testis-specific protein isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables histone binding	IDA IDA: Inferred from direct assay	12861021	MGI
enables histone reader activity	IMP IMP: Inferred from mutant phenotype	22922464	MGI
enables lysine-acetylated histone binding	IMP IMP: Inferred from mutant phenotype	22922464	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20593818	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within chromatin remodeling	IDA IDA: Inferred from direct assay	12861021	MGI
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	19794495	MGI
involved in male meiosis I	IMP IMP: Inferred from mutant phenotype	22922464	MGI
involved in male meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	22922464	MGI
acts upstream of or within positive effect positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22922464	MGI
involved in regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	22570411	MGI
involved in sperm DNA condensation	IMP IMP: Inferred from mutant phenotype	22922464	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	17728347	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	12861021	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Brdt Protein Structure

Bromo_Brdt_I_like

Bromo_Brdt_II_like

BET

BRD4_CDT

0
200
400
600
800
956 a.a.

Protein Preferred Names	Protein Names
bromodomain testis-specific protein	RING3-like protein bromodomain-containing female sterile homeotic-like protein female sterile homeotic-related gene 3

Brdt Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Brdt	Q91Y44	Ccnt1	Mus musculus	Q9QWV9	Anti Bait CoIP	22922464

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-112090	ABBV-744	Inhibitor	99.97%	Phase 1
HY-117286	(S)-JQ-35	Inhibitor	99.46%	Phase 1

Pre-clinical Phase

Bioactive Molecules (21)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-136570	GSK778	Inhibitor	99.14%	Unkown
HY-136571	GSK046	Inhibitor	99.70%	Unkown
HY-138563	GSK973	Inhibitor	99.97%	Unkown
HY-130622	LT052	Inhibitor	98.02%	Unkown
HY-114504	RVX-297	Inhibitor	95.00%	Unkown
HY-112610	CF53	Inhibitor	99.81%	Unkown
HY-131061	BET bromodomain inhibitor 1	Inhibitor	99.67%	Unkown
HY-160558	PLK1/BRD4-IN-3	Inhibitor	98.55%	Unkown
HY-126325	BY27	Inhibitor	/	Unkown
HY-155680	BET BD2-IN-1	Inhibitor	/	Unkown
HY-152213	BET-IN-13	Inhibitor	/	Unkown
HY-182371	BRD4 ligand 15	Ligand	/	Unkown
HY-150684	GXH-II-052	Inhibitor	/	Unkown
HY-149806	Bromodomain IN-2	Inhibitor	/	Unkown
HY-136794	SB-284851-BT	Inhibitor	/	Unkown
HY-183247	BRDT-IN-1	Inhibitor	/	Unkown
HY-150683	NC-III-49-1	Inhibitor	/	Unkown
HY-183248	BRDT-IN-2	Inhibitor	/	Unkown
HY-143471	WNY0824	Inhibitor	/	Unkown
HY-177140	CDD-1147	Inhibitor	/	Unkown
HY-136570A	GSK778 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Brdt	NCBI	NCBI:676