2. Apoptosis Epigenetics
  3. Apoptosis Epigenetic Reader Domain
  4. GSK778 hydrochloride

GSK778 hydrochloride  (Synonyms: iBET-BD1 hydrochloride)

Cat. No.: HY-136570A
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GSK778 (iBET-BD1) hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively.

For research use only. We do not sell to patients.

GSK778 hydrochloride Chemical Structure

GSK778 hydrochloride Chemical Structure

CAS No. : 2863657-79-6

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GSK778 hydrochloride Related Antibodies

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Description

GSK778 (iBET-BD1) hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively[1].

IC50 & Target

BRD2 BD1

75 nM (IC50)

BRD3 BD1

41 nM (IC50)

BRD4-BD1

41 nM (IC50)

BRDT BD1

143 nM (IC50)

Molecular Weight

548.08

Formula

C30H34ClN5O3
CAS No.
SMILES

CC1=NOC(C)=C1C2=C(OC[C@@H]3CNCC3)C=C4C5=C(N=C(COC)N5[C@H](C)C6=CC=CC=C6)C=NC4=C2.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSK778 hydrochloride Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK7782863657-79-6iBET-BD1GSK 778GSK-778ApoptosisEpigenetic Reader DomainBET-BD1Inhibitorinhibitorinhibit

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