GSK778 hydrochloride
Based on 2 publication(s) in Google Scholar
GSK778 (iBET-BD1) hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively.
For research use only. We do not sell to patients.
- CAS No.: 2863657-79-6
- Formula: C30H34ClN5O3
- Molecular Weight:548.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) GSK778 hydrochloride
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Biological Activity
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BRD2 BD1 75 nM (IC50) |
BRD3 BD1 41 nM (IC50) |
BRD4-BD1 41 nM (IC50) |
BRDT BD1 143 nM (IC50) |
Chemical Information
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CAS No. 2863657-79-6
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Molecular Weight 548.08
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Formula C30H34ClN5O3
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SMILES
CC1=NOC(C)=C1C2=C(OC[C@@H]3CNCC3)C=C4C5=C(N=C(COC)N5[C@H](C)C6=CC=CC=C6)C=NC4=C2.Cl
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Synonyms
iBET-BD1 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Nano
Nanopore Discrimination of Protein-Small-Molecule Drug Complexes at Near-Atomic Resolution. [Abstract]2026 May 12;20(18):13624-13635. PMID: 42046448 -
J Pharm Biomed Anal
An online rapid screening HPLC system establishing and applying discovered a new type of natural chemical ligand of the BRD4-BD1 from Hedyotis diffusa. [Abstract]2026 Apr 15:271:117336. PMID: 41512411
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK778 hydrochloride Related Classifications
HY-136570A Related Classifications
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