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Cat. No.: HY-136570A

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GSK778 hydrochloride

Name: GSK778 hydrochloride
Brand: MedChemExpress
SKU: HY-136570A
Availability: PreOrder

(Synonyms: iBET-BD1 hydrochloride)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

GSK778 (iBET-BD1) hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC₅₀s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively.

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CAS No.: 2863657-79-6
Formule: C₃₀H₃₄ClN₅O₃
Masse moléculaire:548.08

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

GSK778 hydrochloride Chemical Structure

CAS No.: 2863657-79-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (2)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

BRD2 BD1

75 nM (IC₅₀)

BRD3 BD1

41 nM (IC₅₀)

BRD4-BD1

41 nM (IC₅₀)

BRDT BD1

143 nM (IC₅₀)

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Chemical Information

CAS No. 2863657-79-6
Masse moléculaire 548.08
Formule C₃₀H₃₄ClN₅O₃
SMILES

CC1=NOC(C)=C1C2=C(OC[C@@H]3CNCC3)C=C4C5=C(N=C(COC)N5[C@H](C)C6=CC=CC=C6)C=NC4=C2.Cl
Synonyms

iBET-BD1 hydrochloride
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

ACS Nano

Nanopore Discrimination of Protein-Small-Molecule Drug Complexes at Near-Atomic Resolution. [Abstract]

2026 May 12;20(18):13624-13635. PMID: 42046448
J Pharm Biomed Anal

An online rapid screening HPLC system establishing and applying discovered a new type of natural chemical ligand of the BRD4-BD1 from Hedyotis diffusa. [Abstract]

2026 Apr 15:271:117336. PMID: 41512411

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Omer G, et, al. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science. 2020 Apr 24; 368(6489): 387-394. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

GSK778 hydrochloride

2 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (2)
Pureté et documentation
Références

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GSK778 hydrochloride

Publications Citing Use of MedChemExpress (MCE) GSK778 hydrochloride

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