2863657-79-6
2863657-79-6
Chemical Structure
GSK778 hydrochloride
Synonym(s): iBET-BD1 hydrochloride
- CAS No.: 2863657-79-6
- Formula:C30H34ClN5O3
- Molecular Weight:548.08
InChIKey: QDTGJCBOHUHPED-DGXMUYMBSA-N
SMILES: CC1=NOC(C)=C1C2=C(OC[C@@H]3CNCC3)C=C4C5=C(N=C(COC)N5[C@H](C)C6=CC=CC=C6)C=NC4=C2.Cl
Biological Activity: GSK778 (iBET-BD1) hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively[1].
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GSK778 hydrochloride | GSK778 (iBET-BD1) hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. | |||||||||||||||||||||
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References
Keywords
