2. Gene
  3. Brdt - bromodomain, testis-specific Gene

Brdt - bromodomain, testis-specific Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Brd6; Fsrg3; 7420412D09Rik

Gene ID: 114642 | Gene type: protein coding

About Brdt

Chromosome 5: 107,479,025-107,534,924 forward strand.GRCm39:CM000998.3

This gene has 4 transcripts (splice variants), 148 orthologues, 11 paralogues and is associated with 18 phenotypes. Biased expression in testis adult (RPKM 12.3), cortex adult (RPKM 1.6) and 6 other tissues.

Summary

The protein encoded by this gene belongs to the BET protein family. BET proteins have two N-terminal bromodomains and one C-terminal extraterminal domain (ET domain). BET proteins regulate chromatin reorganization via binding to acetylated histones. This gene is thought to play a role in the transcriptional regulation of spermatogenesis. Although referred to as testis-specific bromodomain (Brdt) protein, RT-PCR indicates that this gene is expressed in both mouse oocytes and testes. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]

Brdt Products(2)

mRNA Protein Name
NM_054054.2 NP_473395.2 bromodomain testis-specific protein isoform A
NM_001079873.1 NP_001073342.1 bromodomain testis-specific protein isoform B

Brdt Protein Structure

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (25 - 131)

Bromo_Brdt_II_like

Bromo_Brdt_II_like: cd05498 (270 - 371)

BET

BET: pfam17035 (504 - 566)

BRD4_CDT

BRD4_CDT: pfam17105 (913 - 955)

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  • 956 a.a.
Protein Preferred Names Protein Names

bromodomain testis-specific protein

RING3-like protein

bromodomain-containing female sterile homeotic-like protein

female sterile homeotic-related gene 3

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136570 GSK778 Inhibitor 98.93% Unkown
HY-136571 GSK046 Inhibitor 99.65% Unkown
HY-114504 RVX-297 Inhibitor 96.59% Unkown
HY-130622 LT052 Inhibitor 98.77% Unkown
HY-112610 CF53 Inhibitor 99.78% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.91% Unkown
HY-138563 GSK973 Inhibitor 99.46% Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-150684 GXH-II-052 Inhibitor / Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown
HY-136794 SB-284851-BT Inhibitor / Unkown
HY-150683 NC-III-49-1 Inhibitor / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brdt NCBI NCBI:676