Bromodomain IN-2
BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity.
For research use only. We do not sell to patients.
- CAS No.: 2445335-77-1
- Formula: C16H17ClN2O
- Molecular Weight:288.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BRD4(1) 250 nM (Kd) |
BRPF1b 130 nM (Kd) |
BRD7 430 nM (Kd) |
BRD9 67 nM (Kd) |
BRDT (1) 240 nM (Kd) |
CBP 420 nM (Kd) |
CECR2 970 nM (Kd) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAKI-1 | GI50 |
708 nM
Compound: 3
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Growth inhibition of human CAKI-1 cells
Growth inhibition of human CAKI-1 cells
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[PMID: 36736153] |
| DU-145 | GI50 |
13.2 μM
Compound: 3
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Growth inhibition of human DU-145 cells
Growth inhibition of human DU-145 cells
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[PMID: 36736153] |
| NCI-H460 | GI50 |
10.2 μM
Compound: 3
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Growth inhibition of human NCI-H460 cells
Growth inhibition of human NCI-H460 cells
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[PMID: 36736153] |
| SNB-75 | GI50 |
182 nM
Compound: 3
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Growth inhibition of human SNB-75 cells
Growth inhibition of human SNB-75 cells
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[PMID: 36736153] |
| SW-620 | GI50 |
12 μM
Compound: 3
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Growth inhibition of human SW-620 cells
Growth inhibition of human SW-620 cells
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[PMID: 36736153] |
| UO-31 | GI50 |
479 nM
Compound: 3
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Growth inhibition of human UO-31 cells
Growth inhibition of human UO-31 cells
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[PMID: 36736153] |
BD-IN-1 (compound 3; 0-100 µM) shows antiproliferative activity with GI50s of 182, 479, 708 nM for SNB-75, UO-31, CAKI-1 cells, and 13.2, 12.0, 10.2 µM for DU-145, SW-620, NCI-H460 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2445335-77-1
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Molecular Weight 288.77
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Formula C16H17ClN2O
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SMILES
O=C1C2=C(C)NC(C3=C(Cl)C=CC(N)=C3)=C2CCCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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