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  2. Epigenetic Reader Domain
  3. Bromodomain IN-2

Bromodomain IN-2 

Cat. No.: HY-149806
Handling Instructions

BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity.

For research use only. We do not sell to patients.

Bromodomain IN-2 Chemical Structure

Bromodomain IN-2 Chemical Structure

CAS No. : 2445335-77-1

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Description

BD-IN-1 is a pan bromodomain (BD) inhibitor with KD values of 250, 420, 130, 430, 67, 240, 970 nM for BRD4(1), CBP, BRPF1B, BRD7, BRD9, BRDT(1), CECR2 respectively. BD-IN-1 shows antiproliferative activity[1].

IC50 & Target[1]

BRD4(1)

250 nM (Kd)

BRPF1b

130 nM (Kd)

BRD7

430 nM (Kd)

BRD9

67 nM (Kd)

BRDT (1)

240 nM (Kd)

CBP

420 nM (Kd)

CECR2

970 nM (Kd)

In Vitro

BD-IN-1 (compound 3; 0-100 µM) shows antiproliferative activity with GI50s of 182, 479, 708 nM for SNB-75, UO-31, CAKI-1 cells, and 13.2, 12.0, 10.2 µM for DU-145, SW-620, NCI-H460 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

288.77

Formula

C16H17ClN2O

CAS No.
SMILES

O=C1C2=C(C)NC(C3=C(Cl)C=CC(N)=C3)=C2CCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Bromodomain IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Bromodomain IN-2
Cat. No.:
HY-149806
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