2. Gene
  3. BRDT - bromodomain testis associated Gene

BRDT - bromodomain testis associated Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CT9; BRD6; SPGF21

Gene ID: 676 | Gene type: protein coding

About BRDT

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:91,949,371-92,014,428 (from NCBI)

This gene has 24 transcripts (splice variants), 148 orthologues, 11 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 59.8).

Summary

BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

BRDT Products(16)

mRNA Protein Name
XM_047428955.1 XP_047284911.1 bromodomain testis-specific protein isoform X1
XM_006710855.5 XP_006710918.1 bromodomain testis-specific protein isoform X1
XM_047428967.1 XP_047284923.1 bromodomain testis-specific protein isoform X1
XM_011542035.4 XP_011540337.1 bromodomain testis-specific protein isoform X1
XM_011542034.4 XP_011540336.1 bromodomain testis-specific protein isoform X1
XM_011542032.4 XP_011540334.1 bromodomain testis-specific protein isoform X1
NM_001242805.2 NP_001229734.2 bromodomain testis-specific protein isoform b
NM_207189.4 NP_997072.2 bromodomain testis-specific protein isoform b
XM_011542036.4 XP_011540338.1 bromodomain testis-specific protein isoform X1
XM_006710856.5 XP_006710919.1 bromodomain testis-specific protein isoform X1
NM_001242807.2 NP_001229736.2 bromodomain testis-specific protein isoform c
XM_047428949.1 XP_047284905.1 bromodomain testis-specific protein isoform X1
NM_001726.4 NP_001717.3 bromodomain testis-specific protein isoform b
NM_001242806.2 NP_001229735.2 bromodomain testis-specific protein isoform a
NM_001242808.2 NP_001229737.2 bromodomain testis-specific protein isoform c
NM_001242810.2 NP_001229739.2 bromodomain testis-specific protein isoform d

BRDT Protein Structure

Bromodomain

Bromodomain: Bromodomain (39 - 119)

Bromodomain

Bromodomain: Bromodomain (276 - 363)

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  • 947 a.a.
Protein Preferred Names Protein Names

bromodomain testis-specific protein

RING3-like protein

bromodomain, testis-specific

cancer/testis antigen 9

Related Diseases

Diseases Alias
Infertility
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Spermatogenic Failure 16

SPGF16

Acephalic Spermatozoa Syndrome

Spermatozoa, Acephalic
Spermatogenic Failure 21

SPGF21
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc
Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136570 GSK778 Inhibitor 98.93% Unkown
HY-136571 GSK046 Inhibitor 99.65% Unkown
HY-114504 RVX-297 Inhibitor 96.59% Unkown
HY-130622 LT052 Inhibitor 98.77% Unkown
HY-112610 CF53 Inhibitor 99.78% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.91% Unkown
HY-138563 GSK973 Inhibitor 99.46% Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-150684 GXH-II-052 Inhibitor / Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown
HY-136794 SB-284851-BT Inhibitor / Unkown
HY-150683 NC-III-49-1 Inhibitor / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BRDT VGNC VGNC:80149
Rattus norvegicus BRDT RGD RGD:1306678
Macaca mulatta BRDT VGNC VGNC:70282
Canis familiaris BRDT VGNC VGNC:38522
Mus musculus BRDT MGD MGI:1891374
Others BRDT NCBI