Ccl5 - chemokine (C-C motif) ligand 5 Gene

Also Known as SISd; Scya5; RANTES; TCP228; MuRantes

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20304

Summary

Enables CCR1 Chemokine Receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; gonad; hemolymphoid system; late tubule; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5). [provided by Alliance of Genome Resources, Apr 2022]

Ccl5 Products (1)

mRNA Protein Name
NM_013653.3 NP_038681.2 C-C motif chemokine 5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables CCR1 chemokine receptor binding IDA
IDA: Inferred from direct assay
15557190 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
23696660 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
23696660 MGI
involved in negative regulation of macrophage apoptotic process IMP
IMP: Inferred from mutant phenotype
16208318 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
23696660 MGI
involved in positive regulation of monocyte chemotaxis IDA
IDA: Inferred from direct assay
19779041 MGI
acts upstream of or within response to cytokine IDA
IDA: Inferred from direct assay
1375672 MGI
acts upstream of or within response to tumor necrosis factor IDA
IDA: Inferred from direct assay
1375672 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
1375672 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
21148126 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-C motif chemokine 5

  • SIS-delta

  • T-cell-specific protein RANTES

  • small-inducible cytokine A5

Recombinant Ccl5 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71890 RANTES/CCL5 Protein, Mouse P30882 (S24-S91) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78249 RANTES/CCL5 Protein, Mouse (HEK293, Fc) P30882 (S24-S91) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-152293 EVT801 Inhibitor / Phase 1
Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P990638 NI-0701 99.74% Phase 1

Pre-clinical Phase

Bioactive Molecules (28)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-15589 GW9508 99.23% Unkown
HY-122891 SB02024 99.70% Unkown
HY-152956 STING agonist-23 Agonist 99.33% Unkown
HY-152959 STING agonist-26 Agonist 99.56% Unkown
HY-181654 Snail IN-1 Inhibitor 98.27% Unkown
HY-P1949A Cyclic MKEY TFA 98.47% Unkown
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-145491 Resolvin D5 Inhibitor 98.3% Unkown
HY-N12110 SMU-CX1 Inhibitor 99.9% Unkown
HY-15589R GW9508 (Standard) 98.07% Unkown
HY-10109A AS-605240 potassium Inhibitor / Unkown
HY-111198 YM-355179 fumarate / Unkown
HY-152957 STING agonist-24 Agonist / Unkown
HY-152958 STING agonist-25 Agonist / Unkown
HY-152961 STING agonist-28 Agonist / Unkown
HY-175290 Arf1-GEFs-IN-1 Inhibitor / Unkown
HY-178053 AHR agonist 10 / Unkown
HY-182926 Topoisomerase I/II-IN-9 Inhibitor / Unkown
HY-N17963 Cappariloside A Inhibitor / Unkown
HY-P1949 Cyclic MKEY / Unkown
HY-P5836 Citrullinated LL-37 1cit Inhibitor / Unkown
HY-P5837 Citrullinated LL-37 2cit Inhibitor / Unkown
HY-P5838 Citrullinated LL-37 5cit Inhibitor / Unkown
HY-P5843 Citrullinated LL-37 4cit Inhibitor / Unkown
HY-RS02105 CCL5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174751 Human CCL5 mRNA / Unkown
HY-RS16535 Ccl5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22966 Ccl5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P991753 Anti-Mouse CCL5 Antibody (R6G9) Inhibitor 97.24% Unkown
HY-P990677 VLST-002 Inhibitor / Unkown
HY-P991989 MRG004A Antibody 95.44% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccl5 NCBI NCBI:6352