Il1r1 - interleukin 1 receptor type 1 Gene

Also Known as IL-1R-1; IL-1RT1; IL-1RT-1; IL-1R-alpha

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25663

Summary

Enables ionotropic glutamate receptor binding activity. Involved in several processes, including interleukin-1-mediated signaling pathway; positive regulation of neuron migration; and response to odorant. Located in several cellular components, including axon; cell surface; and postsynaptic density. Part of protein-containing complex. Biomarker of pulpitis. Human ortholog(s) of this gene implicated in systemic scleroderma and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Il1r1 Products (2)

mRNA Protein Name
NM_001412593.1 NP_001399522.1 interleukin-1 receptor type 1 precursor
NM_001412594.1 NP_001399523.1 interleukin-1 receptor type 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
21314939 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
19198660 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
20034811 RGD
involved in heat acclimation IMP
IMP: Inferred from mutant phenotype
19022353 RGD
involved in interleukin-1-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
20967881 RGD
involved in positive regulation of neuron migration IMP
IMP: Inferred from mutant phenotype
24950657 RGD
involved in response to epidermal growth factor IEP
IEP: Inferred from expression pattern
9233842 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
10375024 RGD
involved in response to nitric oxide IEP
IEP: Inferred from expression pattern
10375024 RGD
involved in response to odorant IEP
IEP: Inferred from expression pattern
23103411 RGD
involved in response to transforming growth factor beta IEP
IEP: Inferred from expression pattern
9233842 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in axon IDA
IDA: Inferred from direct assay
19732182 RGD
located in cell surface IDA
IDA: Inferred from direct assay
21925583 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17681838 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
21314939 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-1 receptor type 1

  • CD121 antigen-like family member A

  • interleukin 1 beta receptor type 1 short transmembrane form

  • interleukin 1 beta receptor type 1 soluble form

  • interleukin 1 bete receptor type 1 long transmembrane form

  • interleukin-1 receptor alpha

  • interleukin-1 recep

Recombinant Il1r1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P74821 IL-1R1 Protein, Rat (HEK293, His-mFc) A6INN1/NP_037255.3 (L34-K352) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P74822 IL-1R1 Protein, Rat (HEK293, His) NP_037255.3 (L34-K352) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (2)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-108841 Raleukin Antagonist 99.40% Unkown
HY-108822 Rilonacept Inhibitor ≥95.0% Unkown

Pre-clinical Phase

Bioactive Molecules (9)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P1110 AF12198 Inhibitor 99.92% Unkown
HY-P10474 RYTVELA 98.89% Unkown
HY-183344 IL-1β-IN-4 Inhibitor / Unkown
HY-E70731 IRAK4 aa104-460 Recombinant Human Active Protein Kinase / Unkown
HY-N19801 N-Palmitoyl-D-glucosamine / Unkown
HY-RS06720 IL1R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174626 Human IL1R1 mRNA / Unkown
HY-RS20038 Il1r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26541 Il1r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P99140 Anti-Mouse IL-1R Antibody (JAMA-147) Inhibitor 95.00% Unkown
HY-P990321 AMG-108 Inhibitor ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1r1 NCBI NCBI:3554