1. Immunology/Inflammation
  2. Interleukin Related
  3. Rilonacept

Rilonacept  (Synonyms: Arcalyst; IL 1 Trap; Interleukin 1 Trap)

Cat. No.: HY-108822

Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes.

For research use only. We do not sell to patients.

CAS No. : 501081-76-1

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Description

Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes[1].

Species

Human

IC50 & Target[1]

IL-1

 

In Vitro

Rilonacept blocks IL-1α signaling by acting as a soluble decoy receptor that binds IL-1β and prevents its interaction with cell–surface receptors, thereby reducing the inflammatory process[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Rilonacept]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • [IL1RAP (interleukin-1 receptor accessory protein)-IL1R1 (type 1 interleukin-1 receptor, interleukin 1 receptor, type I)]2-IGHG1 Fc (Fragment constant)
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Rilonacept
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