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AMG-108

(Synonyms: MEDI 8968)
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Based on 1 Customer Validation

AMG-108 is a humanized antibody expressed in CHO cells, targeting IL-1R1/CD121a. AMG-108 is composed of a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 144.62 kDa. The isotype control for AMG-108 can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

For research use only. We do not sell to patients.

  • Purity: ≥99.0%
  • Molecular Weight:144.62 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for AMG-108
  • Experimental Validation Results for AMG-108
  • AMG-108 Chemical Structure
    AMG-108 Chemical Structure
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Assay Types
  • 1/16

    Flow cytometric analysis of 1X106 HUVEC cells with AMG-108 (HY-P990321, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized Human IL-1R1/CD121a, His Tag can bind AMG-108. The EC50 for this effect is 4.419 ng/mL.

  • AMG-108 Chemical Structure
    1/16
  • AMG-108
  • Flow cytometric analysis of 1X106 HUVEC cells with AMG-108 (HY-P990321, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized Human IL-1R1/CD121a, His Tag can bind AMG-108. The EC50 for this effect is 4.419 ng/mL.