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AMG-108

(Synonyms: MEDI 8968)
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Based on 1 Customer Validation

AMG-108 (MEDI 8968) is a fully human IgG2 monoclonal antagonist targeting IL‑1R1. AMG-108 binds to the third immunoglobulin domain of the type 1 interleukin-1 receptor (IL-1R1) and non-selectively inhibits the activity of IL-1 alpha and IL-1 beta. The isotype control for AMG-108 can be referred to Human IgG2 kappa, Isotype Control (HY-P99002).

For research use only. We do not sell to patients.

  • Purity : ≥99.0%
  • Molecular Weight:144.62 kDa
  • Storage:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for AMG-108
  • Experimental Validation Results for AMG-108
  • AMG-108 Chemical Structure
    AMG-108 Chemical Structure
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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AMG-108 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All Interleukin Related Isoforms

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100 mg

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Assay Types
  • 1/16

    Flow cytometric analysis of 1X106 HUVEC cells with AMG-108 (HY-P990321, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized Human IL-1R1/CD121a, His Tag can bind AMG-108. The EC50 for this effect is 4.419 ng/mL.

  • AMG-108 Chemical Structure
    1/16
  • AMG-108
  • Flow cytometric analysis of 1X106 HUVEC cells with AMG-108 (HY-P990321, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized Human IL-1R1/CD121a, His Tag can bind AMG-108. The EC50 for this effect is 4.419 ng/mL.