Il21 - interleukin 21 Gene

Also Known as IL-21

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 365769

Summary

Predicted to enable interleukin-2 receptor binding activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune effector process; and tyrosine phosphorylation of STAT protein. Predicted to act upstream of or within positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in asthma; common variable immunodeficiency; hepatocellular carcinoma; and systemic lupus erythematosus. Orthologous to human IL21 (interleukin 21). [provided by Alliance of Genome Resources, Apr 2022]

Il21 Products (1)

mRNA Protein Name
NM_001108943.3 NP_001102413.1 interleukin-21 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Verweise Source
involved in response to dsDNA IEP
IEP: Inferred from expression pattern
18997868 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-21

Recombinant Il21 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P74817 IL-21 Protein, Rat (sf9, His) A3QPB9 (H18-S146) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74818 IL-21 Protein, Rat A3QPB9/NP_001102413.1 (P25-S146) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P991271 NN-8828 Inhibitor 97.89% Phase 2
HY-P991272 ATR-107 Inhibitor 99.9% Phase 1
HY-P99687 Latikafusp Inhibitor 99.40% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-162490 TF-S14 Inhibitor / Unkown
HY-RS06734 IL21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06735 IL21R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06736 IL22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174621 Human IL21R mRNA / Unkown
HY-174622 Human IL21 mRNA / Unkown
HY-RS16691 Il21 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22573 Il21r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23126 Il21 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29091 Il21r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P990218 Anti-Mouse IL-21R Antibody (4A9) 99.96% Unkown
HY-P992241 Anti-IL-21R Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il21 NCBI NCBI:59067