Anti-Mouse IL-21R Antibody (4A9)
Based on 1 Customer Validation
Anti-Mouse IL-21R Antibody (4A9) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-21R. Anti-Mouse IL-21R Antibody (4A9) blocks IL-21 signaling. Anti-Mouse IL-21R Antibody (4A9) can be used for the researches of cancer, infection immunology and inflammation, such as psoriasis, hepatocellular carcinoma and C. rodentium infection.
For research use only. We do not sell to patients.
- Purity : 99.96%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
IL-21R
In Vitro
The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Mouse IL-21R Antibody (4A9) (25 mg/kg, i.p., every the other day from day 35) suppresses fecal C. rodentium-specific IgA and inhibited bacterial clearance in C. rodentium infected mice models[2].
Anti-Mouse IL-21R Antibody (4A9) (140 μg, i.p., at days -2, 0, 1, 3, and 5 of induction) alleviates imiquimod-induced psoriasis-like skin lesion in imiquimod-induced psoriasis mice models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Metabolic dysfunction associated steatohepatitis-driven hepatocellular carcinoma mice models[1]
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Dosage:200 μg
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Administration:Intraperitoneally injection, twice a week for 5 weeks
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Result:Signifcantly reduced tumorigenesis, spleen and liver weight.
Reduced cyclin D1 (Ccnd1), antigen identifed by monoclonal antibody Ki67 and cyclin dependent kinase 4.
Dramatically reduced lipid accumulation and triglyceride and cholesterol levels in the serum and tumor tissue.
Enhanced cytotoxic CD8+ T lymphocyte activation.
Had fewer IgA+ B cells.
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Animal Model:C. rodentium infected micemodels[2]
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Dosage:25 mg/kg
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Administration:Intraperitoneally injection, every the other day from day 35
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Result:Decreased GL7+CD95+ GC B cells in PP, and suppressed total IgA+ B cells and B220+CD138-CD38+IgA+ memory B cells in spleen, PP, and LP.
Decreased B220-CD38-CD138+IgA+ plasma cells.
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Animal Model:Imiquimod-induced psoriasis mice models[3]
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Dosage:140 μg
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Administration:Intraperitoneally injection, at days -2, 0, 1, 3, and 5 of induction
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Result:Inhibited epidermal thickening.
Significantly reduced accumulation of MDSCs in skin lesions and splenic Th17 cells.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo IL-21R blockade
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse IL-21R Antibody (4A9)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Xie Y, et al. Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA+ B cells. Mol Cancer. 2024 May 8;23(1):95. [Content Brief]
[2]. Huang X, et al. IL-21 Promotes Intestinal Memory IgA Responses. J Immunol. 2020 Oct 1;205(7):1944-1952. [Content Brief]
[3]. Chen C, et al. Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy. Mediators Inflamm. 2020 Jun 28;2020:8567320. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse IL-21R Antibody (4A9) Related Classifications
HY-P990218 Related Classifications
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