Anti-Mouse IL-21R Antibody (4A9) 

Anti-Mouse IL-21R Antibody (4A9) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse IL-21R. Anti-Mouse IL-21R Antibody (4A9) blocks IL-21 signaling. Anti-Mouse IL-21R Antibody (4A9) can be used for the researches of cancer, infection immunology and inflammation, such as psoriasis, hepatocellular carcinoma and C. rodentium infection^[1][2][3].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

IL-21R

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-21R Antibody (4A9) (200 μg, i.p., twice a week for 5 weeks) impedes tumor progression in metabolic dysfunction associated steatohepatitis-driven hepatocellular carcinoma mice models^[1].
Anti-Mouse IL-21R Antibody (4A9) (25 mg/kg, i.p., every the other day from day 35) suppresses fecal C. rodentium-specific IgA and inhibited bacterial clearance in C. rodentium infected mice models^[2].
Anti-Mouse IL-21R Antibody (4A9) (140 μg, i.p., at days -2, 0, 1, 3, and 5 of induction) alleviates imiquimod-induced psoriasis-like skin lesion in imiquimod-induced psoriasis mice models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

60504  [NCBI]

Q9JHX3

in vivo IL-21R blockade

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse IL-21R Antibody (4A9)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xie Y, et al. Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA+ B cells. Mol Cancer. 2024 May 8;23(1):95.  [Content Brief]

  [2]. Huang X, et al. IL-21 Promotes Intestinal Memory IgA Responses. J Immunol. 2020 Oct 1;205(7):1944-1952.  [Content Brief]

  [3]. Chen C, et al. Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy. Mediators Inflamm. 2020 Jun 28;2020:8567320.  [Content Brief]