IL21 - interleukin 21 Gene

Also Known as Za11; IL-21; CVID11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 59067

About IL21

Cytogenetic location: 4q27 Genomic coordinates (GRCh38): 4:122,610,108-122,621,066 (from NCBI)

This gene has 3 transcripts (splice variants), 113 orthologues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 3.2), testis (RPKM 0.8) and 2 other tissues.

Summary

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

IL21 Products (2)

mRNA	Protein	Name
NM_001207006.3	NP_001193935.1	interleukin-21 isoform 2 precursor
NM_021803.4	NP_068575.1	interleukin-21 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-2 receptor binding	IPI IPI: Inferred from physical interaction	12504082	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell maturation	IDA IDA: Inferred from direct assay	14635054	GOA
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	17673207	GOA
acts upstream of or within positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	17673207	GOA
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	15207081	GOA
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17673207	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	19322899	GOA
involved in positive regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	16482511	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	18005035	GOA
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	17673207	GOA
involved in tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	12244150	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL21 Protein Structure

IL15

0
100
162 a.a.

Protein Preferred Names	Protein Names
interleukin-21

Recombinant IL21 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7038	IL-21 Protein, Human	Q9HBE4-1 (Q32-S162)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7038G	GMP IL-21 Protein, Human	Q9HBE4-1 (Q30-S162)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78148	IL-21 Protein, Human (His-Avi)	Q9HBE4-1 (Q32-S162)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700112AF	Animal-Free IL-21 Protein, Human (His)	Q9HBE4-1 (Q32-S162)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Immunodeficiency, Common Variable, 11	Il21-Related Infantile Inflammatory Bowel Disease CVID11 Il21 Deficiency Common Variable Immunodeficiency 11 Il21-Related Infantile Ibd Immunodeficiency, Variable, Common, Type 11
Severe Combined Immunodeficiency, X-Linked	X-Linked Severe Combined Immunodeficiency SCIDX1 XSCID Scidx X-Linked Scid X-Scid Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative Scid, X-Linked Immunodeficiency 4 Imd4 Gamma Chain Deficiency Scid-X1 X-Linked Combined Immunodeficiency Diseases Thymic Epithelial Hypoplasia Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency Severe Combined Immunodeficiency T- B+, X-Linked Il2rg Scid, T- B+ Nk- T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency T-B+ Scid Due To Gamma Chain Deficiency T-B+ Severe Combined Immunodeficiency, X-Linked Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative Agammaglobulinemia Swiss Type Scid X-Linked Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Epidermolysis Bullosa Acquisita	Acquired Epidermolysis Bullosa Eb Acquisita Eba Eba - [Epidermolysis Bullosa Acquisita]
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Psoriasis
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991271	NN-8828	Inhibitor	97.89%	Phase 2
HY-P991272	ATR-107	Inhibitor	99.9%	Phase 1
HY-P99687	Latikafusp	Inhibitor	99.40%	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162490	TF-S14	Inhibitor	/	Unkown
HY-RS06734	IL21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06735	IL21R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06736	IL22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174621	Human IL21R mRNA		/	Unkown
HY-174622	Human IL21 mRNA		/	Unkown
HY-RS16691	Il21 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22573	Il21r Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23126	Il21 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29091	Il21r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990218	Anti-Mouse IL-21R Antibody (4A9)		99.96%	Unkown
HY-P992241	Anti-IL-21R Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IL21	VGNC	VGNC:73726
Rattus norvegicus	IL21	RGD	RGD:1307384
Bos taurus	IL21	VGNC	VGNC:30141
Felis catus	IL21	VGNC	VGNC:67774
Mus musculus	IL21	MGD	MGI:1890474
Canis familiaris	IL21	VGNC	VGNC:41967
Others	IL21	NCBI