IL-21 Protein, Rat (sf9, His)

IL-21 protein is an immunomodulatory cytokine that plays a key role in the transition from innate immunity to adaptive immunity. It induces IgG(1) and IgG(3) in B cells, which are critical for T follicular helper (Tfh) cell development, germinal center formation, and robust antibody responses, especially in acute viral infections. IL-21 Protein, Rat (sf9, His) is the recombinant rat-derived IL-21 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of IL-21 Protein, Rat (sf9, His) is 146 a.a., with molecular weight of ~20 kDa.

IL-21 Protein is an immunoregulatory cytokine that plays a crucial role in the transition from innate to adaptive immunity. It induces the production of IgG(1) and IgG(3) in B-cells and is involved in the development and maintenance of T follicular helper (Tfh) cells and the formation of germinal centers. Working in conjunction with IL6, IL-21 Protein is essential for the early generation of Tfh cells and contributes to a robust antibody response during acute viral infections. It also synergizes with IL15 to promote the proliferation and maturation of natural killer (NK) cells and can regulate the proliferation of mature B- and T-cells upon activation. IL-21 Protein, in collaboration with IL15 and IL18, stimulates the production of interferon gamma in T-cells and NK cells. Furthermore, it can inhibit the activation and maturation of dendritic cells during T-cell mediated immune responses.

Rat

Sf9 insect cells

C-His

A3QPB9 (M1-S146)

365769  [NCBI]

Approximately 20 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.