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Art. -Nr.: HY-184542

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HSF1 ligand-1

HSF1 ligand-1 (compound 18) is a ligand for heat shock transcription factor HSF1, as well as a binder for the high-affinity nuclear protein pirin, with an SPR K_d of 44 nM. HSF1 ligand-1 can be used to prepare HSF1-targeted PROTAC degrader (HY-122653).

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CAS. Nr.: 1693735-07-7
Formel: C₂₆H₂₀ClN₃O₄
Molecular Weight:473.91

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

HSF1 ligand-1 Chemical Structure

CAS. Nr.: 1693735-07-7

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Pirin

Alle HSP Isoform-spezifische Produkte anzeigen :

Chemical Information

CAS. Nr. 1693735-07-7
Molecular Weight 473.91
Formel C₂₆H₂₀ClN₃O₄
SMILES

O=C(C1=CC=C2N=C(C)C=CC2=C1)NC3=CC(NC(C4=CC=C(OCCO5)C5=C4)=O)=CC=C3Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Chessum NEA, et al.. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766). Journal of medicinal chemistry. 2018 Feb 08;61(3):918-933. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Konzentration

Volumen

Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
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