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CCT367766 

Cat. No.: HY-122653
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CCT367766 is a potent and the third generation heterobifunctional and PROTAC-based pirin targeting protein degradation probe (PDP), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein.

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CCT367766 Chemical Structure

CCT367766 Chemical Structure

CAS No. : 2229856-58-8

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Description

CCT367766 is a potent and the third generation heterobifunctional and PROTAC-based pirin targeting protein degradation probe (PDP), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein[1].

IC50 & Target[1]

CRBN-DDB1

490 nM (IC50)

In Vitro

CCT367766 (50-1500 nM; 24 hours) demonstates the depletion of pirin protein as a the time-dependent hook-effect in SK-OV-3 human ovarian cancer cells[1].
CCT367766 (0.5-50 nM; 2 hours) demonstrates the concentration-dependent depletion of pirin protein after 2 h exposure in SK-OV-3 cells[1].

Western Blot Analysis[1]

Cell Line: SK-OV-3 human ovarian cancer cells
Concentration: 50, 150, 250, 500 and 1500 nM
Incubation Time: 2 hours, 4 hours, 24 hours
Result: Decreased pirin protein expression.

Western Blot Analysis[1]

Cell Line: SK-OV-3 human ovarian cancer cells
Concentration: 0.5, 1, 2.5, 5, 7.5, 10, 25, and 50 nM
Incubation Time: 2 hours
Result: Completely degraded pirin just at 50 nM treatment.
Molecular Weight

946.40

Formula

C₄₉H₄₈ClN₇O₁₁

CAS No.

2229856-58-8

SMILES

O=C(C1=CC=C2N=C(CN3CCN(CCOCCOCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)CC3)C=CC2=C1)NC7=CC(NC(C8=CC=C(OCCO9)C9=C8)=O)=CC=C7Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CCT367766CCT 367766CCT-367766PROTACProteolysis-targeting chimeraSK-OV-3protacpirinprobeCRBNInhibitorinhibitorinhibit

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CCT367766
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