2. PROTAC
  3. PROTACs
  4. CCT367766

CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (CCT367766 formic) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

CCT367766 Chemical Structure

CCT367766 Chemical Structure

CAS No. : 2229856-58-8

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CCT367766 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein[1].

IC50 & Target[1]

CRBN-DDB1

490 nM (IC50)

In Vitro

CCT367766 (50-1500 nM; 24 hours) demonstates the depletion of pirin protein as a the time-dependent hook-effect in SK-OV-3 human ovarian cancer cells[1].
CCT367766 (0.5-50 nM; 2 hours) demonstrates the concentration-dependent depletion of pirin protein after 2 h exposure in SK-OV-3 cells[1].
CCT367766 (0.5-50 nM; 2 hours) dose-dependently rescuses pirin expression from pretreatment of chlorobisamide in SK-OV-3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCT367766 Related Antibodies

Western Blot Analysis[1]

Cell Line: SK-OV-3 human ovarian cancer cells
Concentration: 50, 150, 250, 500 and 1500 nM
Incubation Time: 2 hours, 4 hours, 24 hours
Result: Decreased pirin protein expression.

Western Blot Analysis[1]

Cell Line: SK-OV-3 human ovarian cancer cells
Concentration: 0.5, 1, 2.5, 5, 7.5, 10, 25, and 50 nM
Incubation Time: 2 hours
Result: Completely degraded pirin just at 50 nM treatment.
Molecular Weight

946.40

Formula

C49H48ClN7O11
CAS No.
SMILES

O=C(C1=CC=C2N=C(CN3CCN(CCOCCOCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)CC3)C=CC2=C1)NC7=CC(NC(C8=CC=C(OCCO9)C9=C8)=O)=CC=C7Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CCT367766 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCT3677662229856-58-8CCT 367766CCT-367766PROTACschemical probesmall molecule therapeuticSK-OV-3protacpirinprobeCRBNInhibitorinhibitorinhibit

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