2. PROTAC
  3. PROTACs
  4. CCT367766 formic

CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein.

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CCT367766 formic Chemical Structure

CCT367766 formic Chemical Structure

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5 mg USD 510 In-stock
10 mg USD 820 In-stock
25 mg USD 1650 In-stock
50 mg USD 2640 In-stock
100 mg USD 4200 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CCT367766 formic:

CCT367766 formic Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein[1].

IC50 & Target

CRBN-DDB1

490 nM (IC50)

In Vitro

CCT367766 formic (50-1500 nM; 24 hours) demonstates the depletion of pirin protein as a the time-dependent hook-effect in SK-OV-3 human ovarian cancer cells[1].
CCT367766 formic (0.5-50 nM; 2 hours) demonstrates the concentration-dependent depletion of pirin protein after 2 h exposure in SK-OV-3 cells[1].
CCT367766 formic (0.5-50 nM; 2 hours) dose-dependently rescuses pirin expression from pretreatment of chlorobisamide in SK-OV-3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCT367766 formic Related Antibodies
Molecular Weight

992.42

Formula

C50H50ClN7O13
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C2N=C(CN3CCN(CCOCCOCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)CC3)C=CC2=C1)NC7=CC(NC(C8=CC=C(OCCO9)C9=C8)=O)=CC=C7Cl.OC=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (251.91 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0076 mL 5.0382 mL 10.0764 mL
5 mM 0.2015 mL 1.0076 mL 2.0153 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0076 mL 5.0382 mL 10.0764 mL 25.1909 mL
5 mM 0.2015 mL 1.0076 mL 2.0153 mL 5.0382 mL
10 mM 0.1008 mL 0.5038 mL 1.0076 mL 2.5191 mL
15 mM 0.0672 mL 0.3359 mL 0.6718 mL 1.6794 mL
20 mM 0.0504 mL 0.2519 mL 0.5038 mL 1.2595 mL
25 mM 0.0403 mL 0.2015 mL 0.4031 mL 1.0076 mL
30 mM 0.0336 mL 0.1679 mL 0.3359 mL 0.8397 mL
40 mM 0.0252 mL 0.1260 mL 0.2519 mL 0.6298 mL
50 mM 0.0202 mL 0.1008 mL 0.2015 mL 0.5038 mL
60 mM 0.0168 mL 0.0840 mL 0.1679 mL 0.4198 mL
80 mM 0.0126 mL 0.0630 mL 0.1260 mL 0.3149 mL
100 mM 0.0101 mL 0.0504 mL 0.1008 mL 0.2519 mL
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CCT367766 formic Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCT367766CCT 367766CCT-367766PROTACschemical probesmall molecule therapeuticSK-OV-3protacpirinprobeCRBNInhibitorinhibitorinhibit

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