2229856-58-8
Chemical Structure
CCT367766
- CAS No.: 2229856-58-8
- Formula:C49H48ClN7O11
- Molecular Weight:946.40
IUPAC Name: N-(2-chloro-5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)phenyl)-2-((4-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)quinoline-6-carboxamide
InChIKey: MYFXVOSCUJQYET-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2N=C(CN3CCN(CCOCCOCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)CC3)C=CC2=C1)NC7=CC(NC(C8=CC=C(OCCO9)C9=C8)=O)=CC=C7Cl
Biological Activity: CCT367766 is a pirin PROTAC degrader. CCT367766 forms a ternary complex with cereblon and induces pirin depletion via the ubiquitin-proteasome pathway in a concentration- and time-dependent manner. CCT367766 can be used for ovarian cancer research[1][2][3].
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CCT367766 | CCT367766 is a pirin PROTAC degrader. CCT367766 forms a ternary complex with cereblon and induces pirin depletion via the ubiquitin-proteasome pathway in a concentration- and time-dependent manner. CCT367766 can be used for ovarian cancer research. | |||||||||||||||||||||
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References
- [1]. Chessum NEA, et al. Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766). Journal of medicinal chemistry. 2018 Feb 08;61(3):918-933. [Content Brief]
- [2]. Sun X, et al. PROTACs: great opportunities for academia and industry. Signal transduction and targeted therapy. 2019;4:64. [Content Brief]
- [3]. Sharp S Y, et al. Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin[J]. Cancer Research, 2018, 78(13_Supplement): 2976-2976.
