LPRP-Et-97543
LPRP-Et-97543 is a potent anti-HBV agent. LPRP-Et-97543 reduces Core, S, and preS but not X promoter activities. LPRP-Et-97543 can be used for acute and chronic HBV infections research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 84638-48-2
- Formel: C17H16O5
- Molecular Weight:300.31
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
LPRP-Et-97543 (0.625-40 μg/ml; 3 days) causes cytotoxic effects at doses >10 μg/ml in HepG2.2.15 and HBV-transfected Huh7 cells[1].LPRP-Et-97543 (2.5-10 μg/ml; 3 days) has inhibitory effects on HBsAg and HBeAg secretions. And the HBeAg inhibition rate is higher than the HBsAg inhibition rate in HepG2.2.15 cells[2].LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) significantly reduces both precore/pregenomic and major S/preS RNA with the LPRP-Et-97543 inhibition potential higher on surface RNA than on the precore/pregenomic RNA[2].LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) potently reduces intracellular LHBsAg and HBcAg protein levels compared to vehicle controls. Additionally, LPRP-Et-97543 potently inhibits the replication HBV DNAlevel in HBV transfected Huh7 cells[2].LPRP-Et-97543 (2.5-10 μg/ml; 2 days after transfected with pHBV1.2 plasmid for 2 days) reduces nuclear p65/p50 NF-κB protein expression and reduces phosphorylated NF-κBp65 in Huh7 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh7 cells with or without pHBV1.2
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Concentration:2.5-10 μg/ml
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Incubation Time:2 days
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Result:Decreased nuclear and nuclear p-p65 expression and increased cytoplasmic IκBα expression.
Chemical Information
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CAS. Nr. 84638-48-2
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Molecular Weight 300.31
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Formel C17H16O5
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SMILES
O=C1[C@H](CC2=CC=C(O)C=C2)COC3=CC(O)=C(C)C(O)=C13
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Tsurng-Juhn Huang, et al. Anti-viral effect of a compound isolated from Liriope platyphylla against hepatitis B virus in vitro.Virus Res. 2014 Nov 4;192:16-24. [Content Brief]
[2]. Yi-Hang Wu, et al. Naturally derived anti-hepatitis B virus agents and their mechanism of action. World J Gastroenterol. 2016 Jan 7;22(1):188-204. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LPRP-Et-97543 Related Classifications
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