PVRIG
PVRIG (CD112R) is an inhibitory immune-checkpoint receptor that binds only to its ligand CD112 (Nectin-2) with high affinity on target cells suppressing lymphocyte cytotoxic function. CD112R is expressed in CD4+ and CD8+T cells, γδ T, NKT, and NK cells. CD112R interacts with CD112 competing with DNAM-1 but not with CD155 (PVR). It has been demonstrated that blocking the CD112-CD112R axis increases effector T-cell function in cancer, suggesting that the CD112-CD112R and CD155-TIGIT pathways could be non-redundant inhibitory signaling pathways.
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PVRIG Recombinant Proteins (14)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
