AGD-0182
AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10. AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- CAS No.: 1835700-14-5
- Formula: C38H63N9O7
- Molecular Weight:757.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KARPAS-299 | IC50 |
0.6 nM
Compound: 83a
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Cytotoxicity against human KARPAS-299 cells assessed as reduction in cell viability incubated for 5 days by Presto blue dye based assay
Cytotoxicity against human KARPAS-299 cells assessed as reduction in cell viability incubated for 5 days by Presto blue dye based assay
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[PMID: 35072477] |
Chemical Information
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CAS No. 1835700-14-5
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Molecular Weight 757.96
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Formula C38H63N9O7
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SMILES
CN[C@@H](C(C)C)C(N[C@@H]([C@H](C)N=[N+]=[N-])C(N(C)[C@@H]([C@@H](C)CC)[C@@H](CC(N1[C@@H](CCC1)[C@H](OC)[C@@H](C)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)=O)OC)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AGD-0182 Related Classifications
HY-144585 Related Classifications
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