Bethanechol chloride
Based on 3 publication(s) in Google Scholar
Bethanechol chloride (Carbamyl-β-methylcholine chloride), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 590-63-6
- Formula: C7H17ClN2O2
- Molecular Weight:196.68
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Bethanechol chloride
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Biological Activity
|
mAChR1 |
mAChR3 |
mAChR4 |
mAChR5 |
Bethanechol chloride (0.3-300 μM) significantly reduces ileal pacemaker potentials[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g) [4]
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Dosage:2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg
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Administration:Intraperitoneal injection
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Result:Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg).
Chemical Information
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CAS No. 590-63-6
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Appearance Solid
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Molecular Weight 196.68
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Formula C7H17ClN2O2
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Color White to off-white
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SMILES
CC(OC(N)=O)C[N+](C)(C)C.[Cl-]
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Synonyms
Carbamyl-β-methylcholine chloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Stem Cell
Vagal pathway activation links chronic stress to decline in intestinal stem cell function. [Abstract]2025 Mar 20:S1934-5909(25)00084-0. PMID: 40120585 -
Acta Pharmacol Sin
Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation. [Abstract]2026 May 29. PMID: 42215618 -
Solvent & Solubility
H2O : ≥ 50 mg/mL (254.22 mM)
DMSO : 11.11 mg/mL (56.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (508.44 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Inderbir S. Padda, et al. Bethanechol. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
[2]. Julia Yuen Hang Liu, et al. Acetylcholine exerts inhibitory and excitatory actions on mouse ileal pacemaker activity: role of muscarinic versus nicotinic receptors. Am J Physiol Gastrointest Liver Physiol. 2020 Jul 1;319(1):G97-G107. [Content Brief]
[3]. M J Fregly, et al. Bethanechol-induced water intake in rats: possible mechanisms of induction. Pharmacol Biochem Behav. 1982 Oct;17(4):727-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.0844 mL | 25.4220 mL | 50.8440 mL | 127.1100 mL |
| 5 mM | 1.0169 mL | 5.0844 mL | 10.1688 mL | 25.4220 mL | |
| 10 mM | 0.5084 mL | 2.5422 mL | 5.0844 mL | 12.7110 mL | |
| 15 mM | 0.3390 mL | 1.6948 mL | 3.3896 mL | 8.4740 mL | |
| 20 mM | 0.2542 mL | 1.2711 mL | 2.5422 mL | 6.3555 mL | |
| 25 mM | 0.2034 mL | 1.0169 mL | 2.0338 mL | 5.0844 mL | |
| 30 mM | 0.1695 mL | 0.8474 mL | 1.6948 mL | 4.2370 mL | |
| 40 mM | 0.1271 mL | 0.6356 mL | 1.2711 mL | 3.1778 mL | |
| 50 mM | 0.1017 mL | 0.5084 mL | 1.0169 mL | 2.5422 mL | |
| H2O | 60 mM | 0.0847 mL | 0.4237 mL | 0.8474 mL | 2.1185 mL |
| 80 mM | 0.0636 mL | 0.3178 mL | 0.6356 mL | 1.5889 mL | |
| 100 mM | 0.0508 mL | 0.2542 mL | 0.5084 mL | 1.2711 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Bethanechol chloride Related Classifications
HY-B0406A Related Classifications
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