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Cat. No.: HY-101521

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CHMFL-BTK-01

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC₅₀ of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation.

For research use only. We do not sell to patients.

CAS No.: 2095280-64-9
Formula: C₃₈H₄₁N₅O₅
Molecular Weight:647.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CHMFL-BTK-01 Chemical Structure

CAS No.: 2095280-64-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC₅₀ of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation^[1].

IC₅₀ & Target

IC50: 7 nM (BTK)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	GI₅₀	2.1 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human MV411 cells Growth inhibition of human MV411 cells	[PMID: 28315597]
NB-4	GI₅₀	6.6 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human NB4 cells Growth inhibition of human NB4 cells	[PMID: 28315597]
OCI-AML-3	GI₅₀	3.8 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human OCI-AML3 cells Growth inhibition of human OCI-AML3 cells	[PMID: 28315597]
Pfeiffer	GI₅₀	4.5 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human Pfeiffer cells Growth inhibition of human Pfeiffer cells	[PMID: 28315597]
Ramos	GI₅₀	3.5 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human Ramos cells Growth inhibition of human Ramos cells	[PMID: 28315597]
SKM-1	GI₅₀	7.1 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human SKM1 cells Growth inhibition of human SKM1 cells	[PMID: 28315597]
SU-DHL-2	GI₅₀	3 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human SU-DHL-2 cells Growth inhibition of human SU-DHL-2 cells	[PMID: 28315597]
U2932	GI₅₀	2.4 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human U2932 cells Growth inhibition of human U2932 cells	[PMID: 28315597]
U-937	GI₅₀	4.8 μM Compound: 9; CHMFL-BTK-01	Growth inhibition of human U937 cells Growth inhibition of human U937 cells	[PMID: 28315597]

Chemical Information

CAS No. 2095280-64-9
Molecular Weight 647.76
Formula C₃₈H₄₁N₅O₅
SMILES

O=C(NC1=CC=CC(C(C=C2NC3=CC=C(C(N4CCOCC4)=O)C(NC(C=C)=O)=C3)=CN(C)C2=O)=C1C)C5=CC=C(C(C)(C)C)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liang Q, et al. Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inh [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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