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Bcl6 - B cell leukemia/lymphoma 6 Gene

Also Known as Bcl5

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12053

Summary

Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including hemopoiesis; negative regulation of signal transduction; and regulation of lymphocyte activation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor). [provided by Alliance of Genome Resources, Apr 2022]

Bcl6 Products (2)

mRNA	Protein	Name
NM_001348026.1	NP_001334955.1	B-cell lymphoma 6 protein homolog
NM_009744.4	NP_033874.1	B-cell lymphoma 6 protein homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12097386	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9110977	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12097386	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	17125145	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	12817026	MGI
enables intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24863065	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9632807	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15659391	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within B cell differentiation	IGI IGI: Inferred from genetic interaction	14647274	MGI
acts upstream of B cell proliferation	IMP IMP: Inferred from mutant phenotype	9171827	MGI
acts upstream of or within Rho protein signal transduction	IGI IGI: Inferred from genetic interaction	15860730	MGI
acts upstream of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	15860730	MGI
acts upstream of T-helper 2 cell differentiation	IGI IGI: Inferred from genetic interaction	12594267	MGI
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15860730	MGI
acts upstream of or within cell morphogenesis	IGI IGI: Inferred from genetic interaction	15860730	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	15860730	MGI
acts upstream of cell motility	IMP IMP: Inferred from mutant phenotype	15860730	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15507530	MGI
acts upstream of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	15860730	MGI
acts upstream of or within erythrocyte development	IMP IMP: Inferred from mutant phenotype	15661395	MGI
acts upstream of or within germinal center formation	IMP IMP: Inferred from mutant phenotype	9110977	MGI
acts upstream of or within heterochromatin formation	IGI IGI: Inferred from genetic interaction	23160044	MGI
acts upstream of isotype switching to IgE isotypes	IGI IGI: Inferred from genetic interaction	10490661	MGI
acts upstream of isotype switching to IgE isotypes	IMP IMP: Inferred from mutant phenotype	10490661	MGI
acts upstream of mast cell cytokine production	IMP IMP: Inferred from mutant phenotype	15950739	MGI
acts upstream of mononuclear cell proliferation	IMP IMP: Inferred from mutant phenotype	15507530	MGI
acts upstream of or within negative regulation of Notch signaling pathway	IGI IGI: Inferred from genetic interaction	23160044	MGI
acts upstream of or within negative regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	15860730	MGI
acts upstream of or within negative regulation of T-helper 2 cell differentiation	IGI IGI: Inferred from genetic interaction	12594267	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	9927203	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11092811	MGI
acts upstream of or within negative regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	15860730	MGI
acts upstream of or within negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	23209284	MGI
acts upstream of or within negative regulation of isotype switching to IgE isotypes	IGI IGI: Inferred from genetic interaction	10490661	MGI
acts upstream of or within negative regulation of isotype switching to IgE isotypes	IMP IMP: Inferred from mutant phenotype	10490661	MGI
acts upstream of or within negative regulation of mast cell cytokine production	IMP IMP: Inferred from mutant phenotype	15950739	MGI
acts upstream of or within negative regulation of mononuclear cell proliferation	IMP IMP: Inferred from mutant phenotype	15507530	MGI
acts upstream of or within negative regulation of plasma cell differentiation	IMP IMP: Inferred from mutant phenotype	15240705	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9632807	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12097386	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9110977	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15611242	MGI
acts upstream of or within negative regulation of type 2 immune response	IGI IGI: Inferred from genetic interaction	10438949	MGI
acts upstream of plasma cell differentiation	IMP IMP: Inferred from mutant phenotype	15240705	MGI
acts upstream of or within positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	9171827	MGI
acts upstream of or within positive regulation of cell motility	IMP IMP: Inferred from mutant phenotype	15860730	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	23160044	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	15860730	MGI
acts upstream of pyramidal neuron differentiation	IDA IDA: Inferred from direct assay	23160044	MGI
acts upstream of or within regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	15860730	MGI
acts upstream of or within regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	15240675	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	9110977	MGI
acts upstream of or within regulation of memory T cell differentiation	IMP IMP: Inferred from mutant phenotype	15240675	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	24863065	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	11092811	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23160044	MGI
acts upstream of or within type 2 immune response	IMP IMP: Inferred from mutant phenotype	9171827	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9632807	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
B-cell lymphoma 6 protein homolog	B-cell leukemia/lymphoma 5

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-172736	BMS-986458	Degrader	99.65%	Phase 2

Pre-clinical Phase

Bioactive Molecules (37)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2334	Glycochenodeoxycholic acid	Activator	99.84%	Unkown
HY-158105	ARV-393	Degrader	99.75%	Unkown
HY-N2334A	Glycochenodeoxycholic acid sodium salt	Activator	98.51%	Unkown
HY-111381	BI-3812	Inhibitor	99.24%	Unkown
HY-156595	BCL6-IN-13		99.66%	Unkown
HY-169245	CDK-TCIP2	Inhibitor	98.94%	Unkown
HY-173552	TCIP3	Inhibitor	99.30%	Unkown
HY-161138	WK369	Inhibitor	99.89%	Unkown
HY-153521	CCT374705	Inhibitor	99.29%	Unkown
HY-173364	EB-TCIP	Inducer	99.58%	Unkown
HY-161989	DZ-837		96.04%	Unkown
HY-186067	PROTAC BCL6 Degrader-3	Degrader	99.76%	Unkown
HY-143653	BCL6-IN-6		98.10%	Unkown
HY-178803	PROTAC BCL6 Degrader-2	Degrader	/	Unkown
HY-173641	MNN-02-155		/	Unkown
HY-122829	BCL6 PROTAC 1	Degrader	/	Unkown
HY-169218	WK692	Inhibitor	/	Unkown
HY-179064	IKZF1/3 ligand-1	Inhibitor	/	Unkown
HY-176382	BCL6 ligand-4		/	Unkown
HY-181084	PROTAC BCL6/GSPT1 Degrader-1	Degrader	/	Unkown
HY-184007	PROTAC BCL6 Degrader-4	Degrader	/	Unkown
HY-164098	JWZ-7-7-Neg1	Inhibitor	/	Unkown
HY-148640	WK500B	Inhibitor	/	Unkown
HY-P10543	SMRT peptide	Inhibitor	/	Unkown
HY-P10566	BCOR(498-514), biotinylated	Inhibitor	/	Unkown
HY-172740	BCL6 ligand-3	Inhibitor	/	Unkown
HY-177756	BCL6-IN-11	Inhibitor	/	Unkown
HY-180166	BCL6-IN-12	Inhibitor	/	Unkown
HY-148631	GSK137	Inhibitor	/	Unkown
HY-161990	BCL6 ligand-2	Inhibitor	/	Unkown
HY-178777	BCL6-760	Degrader	/	Unkown
HY-177755	BCL6-IN-10	Inhibitor	/	Unkown
HY-179075	PROTAC BCL6/IKZF1/3 Degrader-1	Degrader	/	Unkown
HY-186068	BCL6 ligand-9	Ligand	/	Unkown
HY-179317	BCL6 ligand-8	Degrader	/	Unkown
HY-178804	BCL6 ligand-5	Ligand	/	Unkown
HY-168907	OICR11029		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcl6	NCBI	NCBI:604