BCL6 - BCL6 transcription repressor Gene

Also Known as BCL5; LAZ3; BCL6A; ZNF51; ZBTB27

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 604

About BCL6

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:187,721,377-187,745,468 (from NCBI)

This gene has 11 transcripts (splice variants), 274 orthologues, 28 paralogues and is associated with 93 phenotypes. Ubiquitous expression in fat (RPKM 29.2), bone marrow (RPKM 20.1) and 25 other tissues.

Summary

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

BCL6 Products (3)

mRNA Protein Name
NM_001130845.2 NP_001124317.1 B-cell lymphoma 6 protein isoform 1
NM_001134738.1 NP_001128210.1 B-cell lymphoma 6 protein isoform 2
NM_001706.5 NP_001697.2 B-cell lymphoma 6 protein isoform 1
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
15577913 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16704730 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16704730 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
12097386 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12590135 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15577913 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
10898795 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
15577913 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15577913 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
10490843 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11929873 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15577913 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
10490843 GOA
involved in positive regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
20935202 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
7795255 GOA
located in paraspeckles IDA
IDA: Inferred from direct assay
16704730 GOA
colocalizes with replication fork IDA
IDA: Inferred from direct assay
10490843 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL6 Protein Structure

BTB

BTB: BTB/POZ domain (22 - 128)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (560 - 584)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (588 - 612)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (616 - 641)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (645 - 668)

  • 0
  • 200
  • 400
  • 600
  • 706 a.a.
Protein Preferred Names Protein Names

B-cell lymphoma 6 protein

  • B cell CLL/lymphoma 6

BCL6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BCL6 P41182 SPMIP4 Homo sapiens Q8N865 32296183
Intra
BCL6 P41182 SPMIP4 Homo sapiens Q8N865 32296183
Intra
BCL6 P41182 SPMIP4 Homo sapiens Q8N865 32296183
Intra
BCL6 P41182 LIMS4 Homo sapiens P0CW20 25416956
Intra
BCL6 P41182 LIMS4 Homo sapiens P0CW20 32296183
Intra
BCL6 P41182 LIMS4 Homo sapiens P0CW20 32296183
Intra
BCL6 P41182 SPMIP6 Homo sapiens Q8NCR6 32296183
Intra
BCL6 P41182 SPMIP6 Homo sapiens Q8NCR6 32296183
Intra
BCL6 P41182 SPMIP6 Homo sapiens Q8NCR6 32296183
Intra
BCL6 P41182 PBX4 Homo sapiens Q9BYU1 32296183
Intra
BCL6 P41182 PBX4 Homo sapiens Q9BYU1 32296183
Intra
BCL6 P41182 PBX4 Homo sapiens Q9BYU1 32296183
Intra
BCL6 P41182 FBXO11 Homo sapiens Q86XK2 22113614
Intra
BCL6 P41182 FBXO11 Homo sapiens Q86XK2 22113614
Intra
BCL6 P41182 KLHL20 Homo sapiens Q9BS75 32296183
Intra
BCL6 P41182 KLHL20 Homo sapiens Q9BS75 32296183
Intra
BCL6 P41182 KLHL20 Homo sapiens Q9BS75 32296183
Intra
BCL6 P41182 REL Homo sapiens Q04864-2 32296183
Intra
BCL6 P41182 REL Homo sapiens Q04864-2 32296183
Intra
BCL6 P41182 CFAP161 Homo sapiens Q6P656 32296183
Intra
BCL6 P41182 CFAP161 Homo sapiens Q6P656 32296183
Intra
BCL6 P41182 CFAP161 Homo sapiens Q6P656 32296183
Intra
BCL6 P41182 KRTAP13-2 Homo sapiens Q52LG2 32296183
Intra
BCL6 P41182 KRTAP13-2 Homo sapiens Q52LG2 32296183
Intra
BCL6 P41182 KRTAP13-2 Homo sapiens Q52LG2 32296183
Intra
BCL6 P41182 POF1B Homo sapiens Q8WVV4-1 32296183
Intra
BCL6 P41182 POF1B Homo sapiens Q8WVV4-1 32296183
Intra
BCL6 P41182 POF1B Homo sapiens Q8WVV4-1 32296183
Intra
BCL6 P41182 SPMIP2 Homo sapiens Q96LM5 32296183
Intra
BCL6 P41182 SPMIP2 Homo sapiens Q96LM5 32296183
Intra
BCL6 P41182 SPMIP2 Homo sapiens Q96LM5 32296183
Intra
BCL6 P41182 KRTAP19-1 Homo sapiens Q8IUB9 32296183
Intra
BCL6 P41182 KRTAP19-1 Homo sapiens Q8IUB9 32296183
Intra
BCL6 P41182 KRTAP19-1 Homo sapiens Q8IUB9 32296183
Intra
BCL6 P41182 ATP23 Homo sapiens Q9Y6H3 32296183
Intra
BCL6 P41182 ATP23 Homo sapiens Q9Y6H3 32296183
Intra
BCL6 P41182 ATP23 Homo sapiens Q9Y6H3 32296183
Intra
BCL6 P41182 CFAP97D1 Homo sapiens B2RV13 32296183
Intra
BCL6 P41182 CFAP97D1 Homo sapiens B2RV13 32296183
Intra
BCL6 P41182 ANKRD53 Homo sapiens Q8N9V6-2 32296183
Intra
BCL6 P41182 ANKRD53 Homo sapiens Q8N9V6-2 32296183
Intra
BCL6 P41182 ANKRD53 Homo sapiens Q8N9V6-2 32296183
Intra
BCL6 P41182 KIFC3 Homo sapiens Q9BVG8 25416956
Intra
BCL6 P41182 BLZF1 Homo sapiens Q9H2G9 25416956
Intra
BCL6 P41182 BLZF1 Homo sapiens Q9H2G9 32814053
Intra
BCL6 P41182 ARRDC3 Homo sapiens Q96B67 32296183
Intra
BCL6 P41182 ARRDC3 Homo sapiens Q96B67 32296183
Intra
BCL6 P41182 HDAC4 Homo sapiens P56524 16147992
Intra
BCL6 P41182 ZNHIT1 Homo sapiens O43257 32296183
Intra
BCL6 P41182 ZNHIT1 Homo sapiens O43257 32296183
Intra
BCL6 P41182 TRAF2 Homo sapiens Q12933 32296183
Intra
BCL6 P41182 TRAF2 Homo sapiens Q12933 32296183
Intra
BCL6 P41182 TRAF2 Homo sapiens Q12933 32296183
Intra
BCL6 P41182 PFDN5 Homo sapiens Q99471 32296183
Intra
BCL6 P41182 PFDN5 Homo sapiens Q99471 32296183
Intra
BCL6 P41182 PFDN5 Homo sapiens Q99471 32296183
Intra
BCL6 P41182 TRAF1 Homo sapiens Q13077 27107012
Intra
BCL6 P41182 TRAF1 Homo sapiens Q13077 27107012
Intra
BCL6 P41182 TRAF1 Homo sapiens Q13077 25416956
Intra
BCL6 P41182 TP53BP1 Homo sapiens Q12888 32296183
Intra
BCL6 P41182 TP53BP1 Homo sapiens Q12888 32296183
Intra
BCL6 P41182 TP53BP1 Homo sapiens Q12888 32296183
Intra
BCL6 P41182 TRIB3 Homo sapiens Q96RU7 32296183
Intra
BCL6 P41182 TRIB3 Homo sapiens Q96RU7 32296183
Intra
BCL6 P41182 TRIB3 Homo sapiens Q96RU7 32296183
Intra
BCL6 P41182 TRIB3 Homo sapiens Q96RU7 16147992
Intra
BCL6 P41182 PSMB4 Homo sapiens P28070 32296183
Intra
BCL6 P41182 PSMB4 Homo sapiens P28070 32296183
Intra
BCL6 P41182 GOLGA2 Homo sapiens Q08379 32296183
Intra
BCL6 P41182 GOLGA2 Homo sapiens Q08379 27107012
Intra
BCL6 P41182 GOLGA2 Homo sapiens Q08379 32296183
Intra
BCL6 P41182 GOLGA2 Homo sapiens Q08379 32296183
Intra
BCL6 P41182 TLE5 Homo sapiens Q08117 25416956
Intra
BCL6 P41182 ZBTB7B Homo sapiens O15156 25416956
Intra
BCL6 P41182 ZBTB7B Homo sapiens O15156 25416956
Intra
BCL6 P41182 KLHL12 Homo sapiens Q53G59 32296183
Intra
BCL6 P41182 KLHL12 Homo sapiens Q53G59 32296183
Intra
BCL6 P41182 KLHL12 Homo sapiens Q53G59 32296183
Intra
BCL6 P41182 CNOT2 Homo sapiens Q9NZN8 32296183
Intra
BCL6 P41182 CNOT2 Homo sapiens Q9NZN8 32296183
Intra
BCL6 P41182 TEKT4 Homo sapiens Q8WW24 32296183
Intra
BCL6 P41182 TEKT4 Homo sapiens Q8WW24 32296183
Intra
BCL6 P41182 TEKT4 Homo sapiens Q8WW24 32296183
Intra
BCL6 P41182 BCL6 Homo sapiens P41182 32296183
Intra
BCL6 P41182 BCL6 Homo sapiens P41182 32296183
Intra
BCL6 P41182 BCL6 Homo sapiens P41182 25416956
Intra
BCL6 P41182 BCL6 Homo sapiens P41182 32296183
Intra
BCL6 P41182 HDAC9 Homo sapiens Q9UKV0 16147992
Intra
BCL6 P41182 HDAC9 Homo sapiens Q9UKV0 12590135
Intra
BCL6 P41182 ZMYND8 Homo sapiens Q9ULU4 16147992
Intra
BCL6 P41182 WDR83 Homo sapiens Q9BRX9 32296183
Intra
BCL6 P41182 WDR83 Homo sapiens Q9BRX9 32296183
Intra
BCL6 P41182 WDR83 Homo sapiens Q9BRX9 32296183
Intra
BCL6 P41182 PPTC7 Homo sapiens Q8NI37 32296183
Intra
BCL6 P41182 PPTC7 Homo sapiens Q8NI37 32296183
Intra
BCL6 P41182 PPTC7 Homo sapiens Q8NI37 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCL6 Proteins

Cat. No. Product Name Accession Purity
HY-P72102 BCL6 Protein, Human (GST) P41182 (M1-C706) ≥ 90%, as determined by reducing SDS-PAGE.

BCL6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81536 Bcl-6 Antibody (YA1281) IHC-P Human
HY-P81536A Bcl-6 Antibody (YA1281)(PBS only) IHC-P Human
HY-P84303 Bcl-6 Antibody (YA4000) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P84303A Bcl-6 Antibody (YA4000)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P85808 Bcl-6 Antibody (YA5500) WB, ICC/IF, ELISA Human, Mouse,

Related Diseases

Diseases Alias
High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit
  • Hgbl-Dh/Th

  • High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements

  • High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement

Primary Mediastinal Large B-Cell Lymphoma
  • Mediastinal Large B-Cell Lymphoma

  • Large Cell Lymphoma Of The Mediastinum

  • Med-Dlbcl

  • Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

  • Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

  • Mediastinal Large B-Cell Lymphoma

Intravascular Large B-Cell Lymphoma
  • Angioendotheliomatosis Proliferans Systemisata

  • Angiotropic Large Cell Lymphoma

  • Intravascular Lymphomatosis

  • Malignant Angioendotheliomatosis

  • Tappeiner-Pfleger Disease

  • Angioendotheliomatosis

Follicular Lymphoma
  • Lymphoma, Follicular

  • Lymphoma Follicular

  • Brill-Symmers' Disease

  • Large Cell Follicular Non-Hodgkin Lymphoma

  • Diffuse Follicle Centre Lymphoma

  • Diffuse Follicular Lymphoma Nos

  • Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

  • Follicular Large Cell Cleaved Or Noncleaved Lymphoma

  • Large Cell Follicular Noncleaved Lymphoma

  • Follicular Lymphoma With Or Without Diffuse Areas

  • Histiocytic Follicular Lymphoma

  • Histiocytic Nodular Lymphoma

  • Histiocytic Nodular Malignant Lymphoma

  • Large Cell Follicular Lymphoma

  • Large Cell Noncleaved Follicular Lymphoma

  • Large Cell Noncleaved Follicular Malignant Lymphoma

  • Nodular Reticulum Cell Sarcoma

  • Noncleaved Follicular Lymphoma

Lymphoma
  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos

Marginal Zone B-Cell Lymphoma
  • Marginal Zone Lymphoma

  • Mzl

  • Mucosa-Associated Lymphoid Tissue Lymphoma

B-Cell Lymphoma
  • Lymphoma, B-Cell

  • B-Cell Lymphomas

  • B-Cell Lymphocytic Neoplasm

  • Lymphoma B-Cell

  • B-Cell Lymphoma Nos

Gastric Lymphoma
  • Familial Primary Gastric Lymphoma

  • Lymphoma Of The Stomach

  • Primary Gastric Lymphoma

Primary Central Nervous System Lymphoma
  • Pcnsl

  • Primary Cns Lymphoma

  • Primary Brain Lymphoma

  • Primary Lymphoma, Cns

  • Primary Cerebral Lymphoma

Microphthalmia, Syndromic 2
  • Oculofaciocardiodental Syndrome

  • Ofcd Syndrome

  • MCOPS2

  • Microphthalmia, Cataracts, Radiculomegaly, And Septal Heart Defects

  • Syndromic Microphthalmia 2

  • Anop2

  • Cataract-Microphthalmia-Radiculomegaly-Cardiac Septal Defect Syndrome

  • Maa2

  • Microphthalmia Cataracts Radiculomegaly And Septal Heart Defects

  • Syndromic Microphthalmia Type 2

  • Oculo-Facio-Cardio-Dental Syndrome

  • Anop2, Formerly

  • Maa2, Formerly

  • Microphthalmia Syndromic 2

  • Oculo Facio Cardio Dental Syndrome

  • Microphthalmia, Syndromic, 2

  • Marashi-Gorlin Syndrome

  • Microphthalmia, Cataracts, Radiculomegaly And Septal Heart Defects

  • Microphthalmia, Syndromic, Type 2

Angioimmunoblastic T-Cell Lymphoma
  • Immunoblastic Lymphadenopathy

  • Lymphogranulomatosis X

  • T-Cell Lymphoma, Aild Type

  • Aitl

  • Ailt

  • Angioimmunoblastic Lymphadenopathy

  • Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia]

  • Angioimmunoblastic Lymphoma

Peripheral T-Cell Lymphoma
  • Lymphoma T-Cell Peripheral

B-Cell Non-Hodgkin Lymphoma
  • B-Cell Nhl

  • B-Cell Non-Hodgkins Lymphoma

Lymphoma, Mucosa-Associated Lymphoid Type
  • Malt Lymphoma

  • Gastric Lymphoma, Primary

  • Lymphoma, Malt, Somatic

  • Mucosa-Associated Lymphoid Tissue Lymphoma

  • Extranodal Marginal Zone B-Cell Lymphoma

  • MALTOMA

  • Marginal Zone B-Cell Lymphoma

  • Mucosa-Associated Lymphatic Tissue Lymphoma

  • Primary Gastric Lymphoma

  • Gastric Lymphoma

  • Familial Primary Gastric Lymphoma

Reticulosarcoma
  • Histiocytic Lymphoma

  • Large-Cell Lymphomas

  • Lymphoma, Large-Cell

  • Lymphoma Large Cell

  • Diffuse Large B-Cell Lymphoma

  • Histiocytic Sarcoma

Lymphosarcoma
  • Lymphoma

  • Lymphoma, Diffuse

Lymphoma Aids Related
  • Primary Effusion Lymphoma

  • Lymphoma, Aids-Related

  • Aids-Related Lymphoma

  • Pel

  • Aids Related Lymphoma

  • Body Cavity-Based Lymphoma

  • Lymphoma Aids-Related

Lymphoblastic Lymphoma
  • Lymphoma, Lymphoblastic

  • Lymphoma Lymphoblastic

  • Precursor Cell Lymphoblastic Lymphoma

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

Diffuse Large B-Cell Lymphoma
  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma

Burkitt Lymphoma
  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma

Intestinal Disease
  • Intestinal Diseases

Central Nervous System Hematologic Cancer
  • Cns Hematopoietic Tumor

  • Hematopoietic Neoplasm Of Central Nervous System

  • Central Nervous System Hematopoietic Neoplasm

Chest Wall Lymphoma
  • Chest Wall Cancer

  • Lymphoma Of Chest Wall

  • Lymphoma Of The Chest Wall

  • Malignant Neoplasm Of Chest Wall

  • Malignant Tumor Of Chest Wall

Nodal Marginal Zone Lymphoma
  • Mucosa-Associated Lymphoid Tissue Lymphoma

  • Monocytoid B-Cell Lymphoma

Osteonecrosis Of The Jaw
Lymphoma, Non-Hodgkin, Familial
  • Non-Hodgkin Lymphoma

  • Lymphoma, Non-Hodgkin

  • NHL

  • Lymphoma, Non-Hodgkin, Somatic

  • Lymphoma, Follicular, Somatic

  • Familial Non-Hodgkin Lymphoma

  • Lymphoma Non-Hodgkins

  • Follicular Lymphoma, Somatic

  • Lymphosarcoma

  • Non-Hodgkins Lymphoma

Bone Lymphoma
  • Lymphoma Of Bone

  • Lymphoma Of The Bone

Heart Lymphoma
  • Lymphoma Of Heart

  • Cardiac Lymphoma

Paranasal Sinus Lymphoma
  • Lymphoma Of Accessory Sinus

  • Lymphoma Of Paranasal Sinus

Diffuse Large B-Cell Lymphoma Activated B-Cell Type
  • Dlbcl Abc Type

Central Nervous System Lymphoma
  • Microglioma

  • Primary Cns Lymphoma

  • Cns Lymphoma

  • Primary Central Nervous System Lymphoma

Ovarian Lymphoma
Adult Lymphoma
Primary Mediastinal B-Cell Lymphoma
  • Large Cell Lymphoma Of The Mediastinum

  • Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

  • Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Bladder Lymphoma
  • Lymphoma Of The Urinary Bladder

Gastrointestinal Lymphoma
Gallbladder Lymphoma
  • Lymphoma Of The Gallbladder

Prostate Lymphoma
  • Lymphoma Of Prostate

Lymphoma, Hodgkin, Classic
  • Hodgkin Lymphoma

  • Hodgkin Disease

  • Hodgkin'S Lymphoma

  • Hodgkins Lymphoma

  • Classic Hodgkin Lymphoma

  • CHL

  • Hodgkin Lymphoma, Susceptibility To

  • Hl

  • Hodgkin'S Sarcoma

  • Stage I Subdiaphragmatic Hodgkin Lymphoma

  • Stage Ii Subdiaphragmatic Hodgkin Lymphoma

  • Lymphoma, Hodgkin'S

  • Classic Hodgkin Disease

  • Hodgkin'S Disease

  • Lymphoma, Hodgkin, Susceptibility To

  • Hodgkin'S Disease Of Intrapelvic Lymph Nodes

  • Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

  • Malignant Lymphogranuloma

  • Malignant Lymphogranulomatosis

  • Malignant Hodgkin Lymphoma

  • Classical Hodgkin Lymphoma, Type Not Specified

Idiopathic Cd4-Positive T-Lymphocytopenia
  • Idiopathic Cd4 Lymphocytopenia

  • Immunodeficiency 13

  • T-Lymphocytopenia, Idiopathic Cd4-Positive

  • Idiopathic Cd4 Positive T-Lymphocytopenia

  • Icl

  • Idiopathic Cd4 Lymphopenia

  • Imd13

Composite Lymphoma
  • Composite Hodgkin And Non-Hodgkin Lymphoma

Mantle Cell Lymphoma
  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma

Testicular Lymphoma
  • Malignant Lymphoma Of Testis

  • Lymphoma Of The Testis

Lymphoproliferative Syndrome
  • Lymphoproliferative Disorder

  • Lymphoproliferative Disorders

  • Lymphoproliferative Disorders, Susceptibility To

Colon Lymphoma
  • Colonic Lymphoma

  • Lymphoma Of Colon

Breast Lymphoma
  • Lymphoma Of Breast

  • Lymphoma Of The Breast

  • Malignant Lymphoma Of Breast

Appendix Lymphoma
  • Appendiceal Lymphoma

Childhood Lymphoma
  • Pediatric Lymphoma

Hodgkin'S Lymphoma, Lymphocytic-Histiocytic Predominance
  • Hodgkin Disease

  • Hodgkin Lymphoma, Lymphocyte-Rich

  • Hodgkin Lymphoma, Lymphocytic-Histiocytic Predominance

  • Hodgkin'S Disease, Lymphocyte Predominance

  • Lymphocyte Rich Hodgkin'S Disease

  • Lymphocyte Rich Classical Hodgkin Lymphoma

Ureteral Lymphoma
  • Lymphoma Of Ureter

  • Ureter Lymphoma

Acquired Immunodeficiency Syndrome
  • Acquired Immune Deficiency Syndrome

  • AIDS

  • Acquired Immune Deficiency

  • Acquired Immunodeficiency

  • Acquired Immunodeficiency Due To Protein Loss

Eye Lymphoma
  • Malignant Lymphoma Of Eye

  • Lymphoma Of Eye

Spleen Cancer
  • Spleen Neoplasm

  • Splenic Neoplasm

  • Splenic Neoplasms

  • Malignant Splenic Tumor

  • Malignant Tumour Of Spleen

  • Tumor Of Spleen

  • Malignant Neoplasm Of Spleen

Gray Zone Lymphoma
  • B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma

Thyroid Lymphoma
Mature B-Cell Neoplasm
  • Mature B-Cell Lymphocytic Neoplasm

  • Neoplasm Of Mature B-Cells

  • Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Granulomatosis With Polyangiitis
  • GPA

  • Wegener Granulomatosis

  • Wegener Granulomatosis, Formerly

  • Midline Granulomatosis

  • Wg, Formerly

  • Necrotizing Respiratory Granulomatosis

  • Wg

  • Wegeners Granulomatosis

  • Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
  • Cll/Sll

  • B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  • Icdo:9823/3

  • Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

  • Small Cell B-Cell Lymphoma

Splenic Marginal Zone Lymphoma
  • Smzl

  • Splenic Marginal Zone B-Cell Lymphoma

Liver Lymphoma
  • Lymphoma Of Liver

Sternum Cancer
  • Malignant Sternal Neoplasm

  • Neoplasm Of Sternum

Sternum Lymphoma
  • Lymphoma Of Sternum

  • Lymphoma Of The Sternum

Lung Lymphoma
  • Pulmonary Lymphoma

  • Lymphoma Of Lung

  • Primary Lung Lymphoma

Spinal Cord Lymphoma
  • Lymphoma Of The Spinal Cord

  • Spinal Cord Cancer

  • Spine Lymphoma

  • Spinal Cord--Cancer

Small Intestine Lymphoma
  • Small Intestinal Lymphoma

Plasmablastic Lymphoma
  • Pbl

  • Immunoblastic Large-Cell Lymphoma

Intraocular Lymphoma
  • Primary Intraocular Lymphoma

  • Piol

  • Primary Intraocular Non-Hodgkin Lymphoma

  • Primary Intraocular Non-Hodgkin Malignant Lymphoma

Retina Lymphoma
  • Lymphoma Of Retina

  • Retinal Lymphoma

Epiglottis Neoplasm
  • Neoplasm Of Epiglottis

  • Epiglottic Tumor

  • Epiglottic Carcinoma

Pancreas Lymphoma
  • Lymphoma Of Pancreas

Hodgkin'S Lymphoma, Nodular Sclerosis
  • Classical Hodgkin Lymphoma, Nodular Sclerosis

  • Classic Hodgkin Lymphoma, Nodular Sclerosis Type

  • Nodular Sclerosis Hodgkin Lymphoma

  • Hodgkin'S Disease, Nodular Sclerosis

  • Hodgkin Disease, Nodular Sclerosis

  • Hodgkin Lymphoma, Nodular Sclerosis

  • Hodgkin Nodular Sclerosis

Ezb Diffuse Large B-Cell Lymphoma
  • Ezb Dlbcl

  • Doid:0081065

Lymphoplasmacytic Lymphoma
  • Waldenstrom Macroglobulinemia

  • Malignant Lymphoma - Lymphoplasmacytic

  • Waldenström Macroglobulinaemia

  • Waldenström Macroglobulinaemia Without Mention Of Remission

  • Idiopathic Macroglobulinaemia

  • Primary Macroglobulinaemia

Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Syndromic Microphthalmia
  • Microphthalmia, Syndromic

Mature T-Cell And Nk-Cell Lymphoma
  • Mature T-Cell And Natural Killer Cell Lymphoma

  • Nk-T Cell Lymphoma

Retroperitoneal Lymphoma
Immunodeficiency With Hyper-Igm, Type 2
  • HIGM2

  • Hyper-Igm Syndrome Type 2

  • Hyper-Igm Syndrome 2

  • Immunodeficiency With Hyper-Igm Type 2

  • Activation-Induced Cytidine Deaminase Deficiency

  • Aid Deficiency

  • Immunodeficiency With Hyper Igm Type 2

  • Hyper Igm Syndrome 2

  • Immunodeficiency With Hyper-Igm 2

  • Hyper-Igm Immunodeficiency Type 2

  • Immunodeficiency, With Hyper Igm, Type 2

  • Hyper-Igm Immunodeficiency Syndrome, Type 2

Leukemia, Chronic Lymphocytic
  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell

Richter'S Syndrome
  • Richter Syndrome

  • Richter Transformation

Orofaciodigital Syndrome Viii
  • Edwards Syndrome

  • Trisomy 18

  • Complete Trisomy 18 Syndrome

  • OFD8

  • Orofaciodigital Syndrome 8

  • Trisomy 18 Syndrome

  • Oral-Facial-Digital Syndrome With Hypoplastic Epiglottis

  • E3 Trisomy

  • Oral-Facial-Digital Syndrome Type 8

  • Orofaciodigital Syndrome Type 8

  • Ofds Viii

  • Oral-Facial-Digital Syndrome, Type Viii

  • Ofd Syndrome 8

  • Ofds 8

  • Oral Facial Digital Syndrome 8

  • Oral Facial Digital Syndrome Type 8

  • 18 Trisomy

  • Chromosome 18 Trisomy

  • Trisomy 16-18

  • Trisomy E

  • Trisomy E Syndrome

  • Chromosome 18 Duplication

  • Oral-Facial-Digital Syndrome, Edwards Type

  • Orofaciodigital Syndrome, Edwards Type

  • Chromosome 18, Trisomy

  • Cleft Lip/Palate With Abnormal Thumbs And Microcephaly

  • Trisomy 18 Chromosome

  • Abnormal Autosomes 18

Microphthalmia
  • Microphthalmos

  • Isolated Anophthalmia-Microphthalmia Syndrome

  • Isolated Microphthalmia-Anophthalmia-Coloboma

  • Simple Microphthalmos

  • Clinical Anophthalmia

  • Isolated Anophthalmia - Microphthalmia

  • Isolated Pure Microphthalmia

  • Mac Spectrum

  • Microphthalmia-Anophthalmia-Coloboma Spectrum

  • Primitive Anophthalmia

  • Globe Of Eye Small

  • Small Eyeball

  • Hypoplasia Of Eye

  • Isolated Nanophthalmos

  • Rudimentary Eye

  • Dysplasia Of Eye

Multicentric Castleman Disease
  • Mcd

  • Multicentric Giant Lymph Node Hyperplasia

  • Plasmablastic Multicentric Castleman Disease

  • Pmcd

  • Idiopathic Multicentric Castleman Disease

  • Multi-Centric Castleman'S Disease

  • Idiopathic Multicentric Castleman'S Disease

  • Multicentric Plasma Cell Variant Of Castleman'S Disease

  • Hhv-8-Negative Multicentric Castleman Disease

  • Human Herpesvirus-8-Negative Multicentric Castleman Disease

Lung Cancer
  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma

Pleural Empyema
  • Empyema

  • Pyothorax

  • Empyema, Pleural

  • Abscess Of Pleural Cavity

  • Abscess Of Thorax

  • Empyema Of Pleura

  • Empyema Of Pleura Without Fistula

  • Empyema With Fistula

  • Empyema With No Fistula

  • Empyema With Pleural Fistula

  • Empyema Without Mention Of Fistula

  • Empyema, Chest

  • Lung Empyema

  • Pleural Empyema With Fistula

  • Pleural Empyema With No Fistula

  • Purulent Pleurisy

  • Purulent Pleuritis

  • Thorax Abscess

  • Pyopneumothorax

Acute Promyelocytic Leukemia
  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic

Lymphatic System Cancer
Lymphatic System Disease
  • Lymphatic Diseases

  • Adenopathy

  • Lymphatic Disease

  • Disease Of Lympoid System

  • Disorder Of Lymph Node And Lymphatics

  • Disorder Of Lymphatic System

  • Disorder Of Lymphoid System

  • Lymphangiopathy

  • Lymphatic Disorder

  • Lympoid System Disease

  • Abnormality Of The Lymphatic System

Hypertrichosis
Splenic Disease
  • Splenic Diseases

  • Dyssplenism

  • Spleen Disease

  • Abnormality Of The Spleen

  • Spleen Diseases

Immune Deficiency Disease
  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm

Leukemia, Acute Lymphoblastic
  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Medulloblastoma
  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site

Sezary'S Disease
  • Sezary Syndrome

  • Sézary Syndrome

  • Sezary'S Lymphoma

  • Sezary Disease

  • Sezary Erythroderma

  • Sezary Lymphoma

Potocki-Shaffer Syndrome
  • Proximal 11p Deletion Syndrome

  • Chromosome 11p11.2 Deletion Syndrome

  • Pss

  • 11p11.2 Deletion

  • P11pds

  • Defect11 Syndrome

  • Deletion Of Chromosome 11p11.2

  • POSHS

Myeloma, Multiple
  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]

Fanconi Anemia, Complementation Group A
  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia

Leukemia, Acute Myeloid
  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus BCL6 VGNC VGNC:60087
Mus musculus BCL6 MGD MGI:107187
Macaca mulatta BCL6 VGNC VGNC:70036
Bos taurus BCL6 VGNC VGNC:58471
Canis familiaris BCL6 VGNC VGNC:96539
Rattus norvegicus BCL6 RGD RGD:1309345
Others BCL6 NCBI