BCL6 - BCL6 transcription repressor Gene
Also Known as BCL5; LAZ3; BCL6A; ZNF51; ZBTB27
Species: Homo sapiens
About BCL6
This gene has 11 transcripts (splice variants), 274 orthologues, 28 paralogues and is associated with 93 phenotypes. Ubiquitous expression in fat (RPKM 29.2), bone marrow (RPKM 20.1) and 25 other tissues.
Summary
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
BCL6 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001130845.2 | NP_001124317.1 | B-cell lymphoma 6 protein isoform 1 |
| NM_001134738.1 | NP_001128210.1 | B-cell lymphoma 6 protein isoform 2 |
| NM_001706.5 | NP_001697.2 | B-cell lymphoma 6 protein isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables DNA-binding transcription factor activity |
IMP
IMP: Inferred from mutant phenotype
|
15577913 | GOA |
| enables DNA-binding transcription factor binding |
IPI
IPI: Inferred from physical interaction
|
16704730 | GOA |
| enables DNA-binding transcription repressor activity, RNA polymerase II-specific |
IDA
IDA: Inferred from direct assay
|
16704730 | GOA |
| enables chromatin binding |
IDA
IDA: Inferred from direct assay
|
12097386 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12590135 | GOA |
| enables sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
15577913 | GOA |
| enables sequence-specific double-stranded DNA binding |
IDA
IDA: Inferred from direct assay
|
28473536 | GOA |
| enables transcription corepressor binding |
IPI
IPI: Inferred from physical interaction
|
10898795 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in DNA damage response |
IDA
IDA: Inferred from direct assay
|
15577913 | GOA |
| involved in negative regulation of DNA-templated transcription |
IMP
IMP: Inferred from mutant phenotype
|
15577913 | GOA |
| involved in negative regulation of cell growth |
IDA
IDA: Inferred from direct assay
|
10490843 | GOA |
| acts upstream of or within negative regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
11929873 | GOA |
| involved in negative regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
15577913 | GOA |
| involved in positive regulation of apoptotic process |
IDA
IDA: Inferred from direct assay
|
10490843 | GOA |
| involved in positive regulation of regulatory T cell differentiation |
IMP
IMP: Inferred from mutant phenotype
|
20935202 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
7795255 | GOA |
| located in paraspeckles |
IDA
IDA: Inferred from direct assay
|
16704730 | GOA |
| colocalizes with replication fork |
IDA
IDA: Inferred from direct assay
|
10490843 | GOA |
BCL6 Protein Structure
BTB: BTB/POZ domain (22 - 128)
zf-H2C2_2: Zinc-finger double domain (560 - 584)
zf-H2C2_2: Zinc-finger double domain (588 - 612)
zf-H2C2_2: Zinc-finger double domain (616 - 641)
zf-H2C2_2: Zinc-finger double domain (645 - 668)
- 0
- 200
- 400
- 600
- 706 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
B-cell lymphoma 6 protein |
|
BCL6 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
BCL6 | P41182 | SPMIP4 | Homo sapiens | Q8N865 | 32296183 | |
|
Intra
|
BCL6 | P41182 | SPMIP4 | Homo sapiens | Q8N865 | 32296183 | |
|
Intra
|
BCL6 | P41182 | SPMIP4 | Homo sapiens | Q8N865 | 32296183 | |
|
Intra
|
BCL6 | P41182 | LIMS4 | Homo sapiens | P0CW20 | 25416956 | |
|
Intra
|
BCL6 | P41182 | LIMS4 | Homo sapiens | P0CW20 | 32296183 | |
|
Intra
|
BCL6 | P41182 | LIMS4 | Homo sapiens | P0CW20 | 32296183 | |
|
Intra
|
BCL6 | P41182 | SPMIP6 | Homo sapiens | Q8NCR6 | 32296183 | |
|
Intra
|
BCL6 | P41182 | SPMIP6 | Homo sapiens | Q8NCR6 | 32296183 | |
|
Intra
|
BCL6 | P41182 | SPMIP6 | Homo sapiens | Q8NCR6 | 32296183 | |
|
Intra
|
BCL6 | P41182 | PBX4 | Homo sapiens | Q9BYU1 | 32296183 | |
|
Intra
|
BCL6 | P41182 | PBX4 | Homo sapiens | Q9BYU1 | 32296183 | |
|
Intra
|
BCL6 | P41182 | PBX4 | Homo sapiens | Q9BYU1 | 32296183 | |
|
Intra
|
BCL6 | P41182 | FBXO11 | Homo sapiens | Q86XK2 | 22113614 | |
|
Intra
|
BCL6 | P41182 | FBXO11 | Homo sapiens | Q86XK2 | 22113614 | |
|
Intra
|
BCL6 | P41182 | KLHL20 | Homo sapiens | Q9BS75 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KLHL20 | Homo sapiens | Q9BS75 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KLHL20 | Homo sapiens | Q9BS75 | 32296183 | |
|
Intra
|
BCL6 | P41182 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
BCL6 | P41182 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
BCL6 | P41182 | CFAP161 | Homo sapiens | Q6P656 | 32296183 | |
|
Intra
|
BCL6 | P41182 | CFAP161 | Homo sapiens | Q6P656 | 32296183 | |
|
Intra
|
BCL6 | P41182 | CFAP161 | Homo sapiens | Q6P656 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
BCL6 | P41182 | POF1B | Homo sapiens | Q8WVV4-1 | 32296183 | |
|
Intra
|
BCL6 | P41182 | POF1B | Homo sapiens | Q8WVV4-1 | 32296183 | |
|
Intra
|
BCL6 | P41182 | POF1B | Homo sapiens | Q8WVV4-1 | 32296183 | |
|
Intra
|
BCL6 | P41182 | SPMIP2 | Homo sapiens | Q96LM5 | 32296183 | |
|
Intra
|
BCL6 | P41182 | SPMIP2 | Homo sapiens | Q96LM5 | 32296183 | |
|
Intra
|
BCL6 | P41182 | SPMIP2 | Homo sapiens | Q96LM5 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KRTAP19-1 | Homo sapiens | Q8IUB9 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KRTAP19-1 | Homo sapiens | Q8IUB9 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KRTAP19-1 | Homo sapiens | Q8IUB9 | 32296183 | |
|
Intra
|
BCL6 | P41182 | ATP23 | Homo sapiens | Q9Y6H3 | 32296183 | |
|
Intra
|
BCL6 | P41182 | ATP23 | Homo sapiens | Q9Y6H3 | 32296183 | |
|
Intra
|
BCL6 | P41182 | ATP23 | Homo sapiens | Q9Y6H3 | 32296183 | |
|
Intra
|
BCL6 | P41182 | CFAP97D1 | Homo sapiens | B2RV13 | 32296183 | |
|
Intra
|
BCL6 | P41182 | CFAP97D1 | Homo sapiens | B2RV13 | 32296183 | |
|
Intra
|
BCL6 | P41182 | ANKRD53 | Homo sapiens | Q8N9V6-2 | 32296183 | |
|
Intra
|
BCL6 | P41182 | ANKRD53 | Homo sapiens | Q8N9V6-2 | 32296183 | |
|
Intra
|
BCL6 | P41182 | ANKRD53 | Homo sapiens | Q8N9V6-2 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KIFC3 | Homo sapiens | Q9BVG8 | 25416956 | |
|
Intra
|
BCL6 | P41182 | BLZF1 | Homo sapiens | Q9H2G9 | 25416956 | |
|
Intra
|
BCL6 | P41182 | BLZF1 | Homo sapiens | Q9H2G9 | 32814053 | |
|
Intra
|
BCL6 | P41182 | ARRDC3 | Homo sapiens | Q96B67 | 32296183 | |
|
Intra
|
BCL6 | P41182 | ARRDC3 | Homo sapiens | Q96B67 | 32296183 | |
|
Intra
|
BCL6 | P41182 | HDAC4 | Homo sapiens | P56524 | 16147992 | |
|
Intra
|
BCL6 | P41182 | ZNHIT1 | Homo sapiens | O43257 | 32296183 | |
|
Intra
|
BCL6 | P41182 | ZNHIT1 | Homo sapiens | O43257 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
BCL6 | P41182 | PFDN5 | Homo sapiens | Q99471 | 32296183 | |
|
Intra
|
BCL6 | P41182 | PFDN5 | Homo sapiens | Q99471 | 32296183 | |
|
Intra
|
BCL6 | P41182 | PFDN5 | Homo sapiens | Q99471 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TRAF1 | Homo sapiens | Q13077 | 27107012 | |
|
Intra
|
BCL6 | P41182 | TRAF1 | Homo sapiens | Q13077 | 27107012 | |
|
Intra
|
BCL6 | P41182 | TRAF1 | Homo sapiens | Q13077 | 25416956 | |
|
Intra
|
BCL6 | P41182 | TP53BP1 | Homo sapiens | Q12888 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TP53BP1 | Homo sapiens | Q12888 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TP53BP1 | Homo sapiens | Q12888 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TRIB3 | Homo sapiens | Q96RU7 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TRIB3 | Homo sapiens | Q96RU7 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TRIB3 | Homo sapiens | Q96RU7 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TRIB3 | Homo sapiens | Q96RU7 | 16147992 | |
|
Intra
|
BCL6 | P41182 | PSMB4 | Homo sapiens | P28070 | 32296183 | |
|
Intra
|
BCL6 | P41182 | PSMB4 | Homo sapiens | P28070 | 32296183 | |
|
Intra
|
BCL6 | P41182 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
BCL6 | P41182 | GOLGA2 | Homo sapiens | Q08379 | 27107012 | |
|
Intra
|
BCL6 | P41182 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
BCL6 | P41182 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TLE5 | Homo sapiens | Q08117 | 25416956 | |
|
Intra
|
BCL6 | P41182 | ZBTB7B | Homo sapiens | O15156 | 25416956 | |
|
Intra
|
BCL6 | P41182 | ZBTB7B | Homo sapiens | O15156 | 25416956 | |
|
Intra
|
BCL6 | P41182 | KLHL12 | Homo sapiens | Q53G59 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KLHL12 | Homo sapiens | Q53G59 | 32296183 | |
|
Intra
|
BCL6 | P41182 | KLHL12 | Homo sapiens | Q53G59 | 32296183 | |
|
Intra
|
BCL6 | P41182 | CNOT2 | Homo sapiens | Q9NZN8 | 32296183 | |
|
Intra
|
BCL6 | P41182 | CNOT2 | Homo sapiens | Q9NZN8 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TEKT4 | Homo sapiens | Q8WW24 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TEKT4 | Homo sapiens | Q8WW24 | 32296183 | |
|
Intra
|
BCL6 | P41182 | TEKT4 | Homo sapiens | Q8WW24 | 32296183 | |
|
Intra
|
BCL6 | P41182 | BCL6 | Homo sapiens | P41182 | 32296183 | |
|
Intra
|
BCL6 | P41182 | BCL6 | Homo sapiens | P41182 | 32296183 | |
|
Intra
|
BCL6 | P41182 | BCL6 | Homo sapiens | P41182 | 25416956 | |
|
Intra
|
BCL6 | P41182 | BCL6 | Homo sapiens | P41182 | 32296183 | |
|
Intra
|
BCL6 | P41182 | HDAC9 | Homo sapiens | Q9UKV0 | 16147992 | |
|
Intra
|
BCL6 | P41182 | HDAC9 | Homo sapiens | Q9UKV0 | 12590135 | |
|
Intra
|
BCL6 | P41182 | ZMYND8 | Homo sapiens | Q9ULU4 | 16147992 | |
|
Intra
|
BCL6 | P41182 | WDR83 | Homo sapiens | Q9BRX9 | 32296183 | |
|
Intra
|
BCL6 | P41182 | WDR83 | Homo sapiens | Q9BRX9 | 32296183 | |
|
Intra
|
BCL6 | P41182 | WDR83 | Homo sapiens | Q9BRX9 | 32296183 | |
|
Intra
|
BCL6 | P41182 | PPTC7 | Homo sapiens | Q8NI37 | 32296183 | |
|
Intra
|
BCL6 | P41182 | PPTC7 | Homo sapiens | Q8NI37 | 32296183 | |
|
Intra
|
BCL6 | P41182 | PPTC7 | Homo sapiens | Q8NI37 | 32296183 |
Recombinant BCL6 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72102 | BCL6 Protein, Human (GST) | P41182 (M1-C706) | ≥ 90%, as determined by reducing SDS-PAGE. |
BCL6 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81536 | Bcl-6 Antibody (YA1281) | IHC-P | Human |
| HY-P81536A | Bcl-6 Antibody (YA1281)(PBS only) | IHC-P | Human |
| HY-P84303 | Bcl-6 Antibody (YA4000) | WB, IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P84303A | Bcl-6 Antibody (YA4000)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P85808 | Bcl-6 Antibody (YA5500) | WB, ICC/IF, ELISA | Human, Mouse, |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit |
|
|
| Primary Mediastinal Large B-Cell Lymphoma |
|
|
| Intravascular Large B-Cell Lymphoma |
|
|
| Follicular Lymphoma |
|
|
| Lymphoma |
|
|
| Marginal Zone B-Cell Lymphoma |
|
|
| B-Cell Lymphoma |
|
|
| Gastric Lymphoma |
|
|
| Primary Central Nervous System Lymphoma |
|
|
| Microphthalmia, Syndromic 2 |
|
|
| Angioimmunoblastic T-Cell Lymphoma |
|
|
| Peripheral T-Cell Lymphoma |
|
|
| B-Cell Non-Hodgkin Lymphoma |
|
|
| Lymphoma, Mucosa-Associated Lymphoid Type |
|
|
| Reticulosarcoma |
|
|
| Lymphosarcoma |
|
|
| Lymphoma Aids Related |
|
|
| Lymphoblastic Lymphoma |
|
|
| Diffuse Large B-Cell Lymphoma |
|
|
| Burkitt Lymphoma |
|
|
| Intestinal Disease |
|
|
| Central Nervous System Hematologic Cancer |
|
|
| Chest Wall Lymphoma |
|
|
| Nodal Marginal Zone Lymphoma |
|
|
| Osteonecrosis Of The Jaw |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Bone Lymphoma |
|
|
| Heart Lymphoma |
|
|
| Paranasal Sinus Lymphoma |
|
|
| Diffuse Large B-Cell Lymphoma Activated B-Cell Type |
|
|
| Central Nervous System Lymphoma |
|
|
| Ovarian Lymphoma |
|
|
| Adult Lymphoma |
|
|
| Primary Mediastinal B-Cell Lymphoma |
|
|
| Bladder Lymphoma |
|
|
| Gastrointestinal Lymphoma |
|
|
| Gallbladder Lymphoma |
|
|
| Prostate Lymphoma |
|
|
| Lymphoma, Hodgkin, Classic |
|
|
| Idiopathic Cd4-Positive T-Lymphocytopenia |
|
|
| Composite Lymphoma |
|
|
| Mantle Cell Lymphoma |
|
|
| Testicular Lymphoma |
|
|
| Lymphoproliferative Syndrome |
|
|
| Colon Lymphoma |
|
|
| Breast Lymphoma |
|
|
| Appendix Lymphoma |
|
|
| Childhood Lymphoma |
|
|
| Hodgkin'S Lymphoma, Lymphocytic-Histiocytic Predominance |
|
|
| Ureteral Lymphoma |
|
|
| Acquired Immunodeficiency Syndrome |
|
|
| Eye Lymphoma |
|
|
| Spleen Cancer |
|
|
| Gray Zone Lymphoma |
|
|
| Thyroid Lymphoma |
|
|
| Mature B-Cell Neoplasm |
|
|
| Granulomatosis With Polyangiitis |
|
|
| Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma |
|
|
| Splenic Marginal Zone Lymphoma |
|
|
| Liver Lymphoma |
|
|
| Sternum Cancer |
|
|
| Sternum Lymphoma |
|
|
| Lung Lymphoma |
|
|
| Spinal Cord Lymphoma |
|
|
| Small Intestine Lymphoma |
|
|
| Plasmablastic Lymphoma |
|
|
| Intraocular Lymphoma |
|
|
| Retina Lymphoma |
|
|
| Epiglottis Neoplasm |
|
|
| Pancreas Lymphoma |
|
|
| Hodgkin'S Lymphoma, Nodular Sclerosis |
|
|
| Ezb Diffuse Large B-Cell Lymphoma |
|
|
| Lymphoplasmacytic Lymphoma |
|
|
| Relapsed/Refractory Diffuse Large B-Cell Lymphoma |
|
|
| Syndromic Microphthalmia |
|
|
| Mature T-Cell And Nk-Cell Lymphoma |
|
|
| Retroperitoneal Lymphoma |
|
|
| Immunodeficiency With Hyper-Igm, Type 2 |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Richter'S Syndrome |
|
|
| Orofaciodigital Syndrome Viii |
|
|
| Microphthalmia |
|
|
| Multicentric Castleman Disease |
|
|
| Lung Cancer |
|
|
| Pleural Empyema |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Lymphatic System Cancer |
|
|
| Lymphatic System Disease |
|
|
| Hypertrichosis |
|
|
| Splenic Disease |
|
|
| Immune Deficiency Disease |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Medulloblastoma |
|
|
| Sezary'S Disease |
|
|
| Potocki-Shaffer Syndrome |
|
|
| Myeloma, Multiple |
|
|
| Fanconi Anemia, Complementation Group A |
|
|
| Leukemia, Acute Myeloid |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | BCL6 | VGNC | VGNC:60087 |
| Mus musculus | BCL6 | MGD | MGI:107187 |
| Macaca mulatta | BCL6 | VGNC | VGNC:70036 |
| Bos taurus | BCL6 | VGNC | VGNC:58471 |
| Canis familiaris | BCL6 | VGNC | VGNC:96539 |
| Rattus norvegicus | BCL6 | RGD | RGD:1309345 |
| Others | BCL6 | NCBI |