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Art. -Nr.: HY-178700

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ALV-05-151-02

ALV-05-151-02 is a BCL6B zinc finger protein degrader that selectively targets BCL6B over BCL6. ALV-05-151-02 redirects the E3 ubiquitin ligase CRL4_CRBN to induce BCL6B degradation and interacts with the H357 residue of BCL6B.

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CAS. Nr.: 2744249-11-2
Formel: C₂₇H₂₈F₃N₅O₄
Molecular Weight:543.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

ALV-05-151-02 Chemical Structure

CAS. Nr.: 2744249-11-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

BCL6B

In Vitro

ALV-05-151-02 (18 h) selectively induces degradation of the BCL6B ZF reporter in U937 cells, but not the BCL6 ZF reporter, due to favorable interactions between BCL6B H357 and the compound's tertiary amine group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS. Nr. 2744249-11-2
Molecular Weight 543.54
Formel C₂₇H₂₈F₃N₅O₄
SMILES

CN(C)C(CC(NC1=CC=CC(C(F)(F)F)=C1)=O)C2=CC(NC3=CCN(C4C(NC(CC4)=O)=O)C3=O)=CC=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Słabicki M, et al. Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Molecular cell. 2025 Aug 21;85(16):3184-3201.e14. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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