2. PROTAC Immunology/Inflammation
  3. PROTACs BCL6
  4. PROTAC BCL6 Degrader-4

PROTAC BCL6 Degrader-4 is a potent PROTAC BCL6 degrader. PROTAC BCL6 Degrader-4 recruits CRBN E3 ligase machinery to promote ubiquitination and proteasomal degradation of BCL6. PROTAC BCL6 Degrader-4 can be used for the research of diffuse large B-cell lymphoma and related hematological malignancies.

For research use only. We do not sell to patients.

PROTAC BCL6 Degrader-4

PROTAC BCL6 Degrader-4 Chemical Structure

CAS No. : 3121287-19-9

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PROTAC BCL6 Degrader-4 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC BCL6 Degrader-4 is a potent PROTAC BCL6 degrader. PROTAC BCL6 Degrader-4 recruits CRBN E3 ligase machinery to promote ubiquitination and proteasomal degradation of BCL6. PROTAC BCL6 Degrader-4 can be used for the research of diffuse large B-cell lymphoma and related hematological malignancies[1].

In Vitro

PROTAC BCL6 Degrader-4 (compound 12) potently degrades BCL6 in T47D cells with a DC50 of <5 nM and achieves ≥70% maximum degradation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC BCL6 Degrader-4 Related Antibodies
Molecular Weight

925.42

Formula

C47H51ClF2N10O6
CAS No.
SMILES

CN1C(C2=C(C3=C1C=CC(NC4=NC(N5CCC(CC5)O[C@H]6C[C@@H](C6)N7CCC(CC7)C8=CC9=C(C(N(N=C9)C%10CCC(NC%10=O)=O)=O)C=C8)=NC=C4Cl)=C3)N[C@H](C(F)(CO2)F)C%11CC%11)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC BCL6 Degrader-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BCL6 Degrader-43121287-19-9PROTACsBCL6B-cell lymphoma 6 proteinB-cell lymphoma 5 protein (BCL-5)Zinc finger and BTB domain-containing protein 27Zinc finger protein 51lymphoma modelsproteasomal degradationdiffuse large B-cell lymphomahematological malignanciesE3 ligase machineryT47D cellsubiquitinationCRBNcereblonInhibitorinhibitorinhibit

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