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Cat. No.: HY-184007

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PROTAC BCL6 Degrader-4

PROTAC BCL6 Degrader-4 is a potent PROTAC BCL6 degrader. PROTAC BCL6 Degrader-4 recruits CRBN E3 ligase machinery to promote ubiquitination and proteasomal degradation of BCL6. PROTAC BCL6 Degrader-4 can be used for the research of diffuse large B-cell lymphoma and related hematological malignancies.

For research use only. We do not sell to patients.

CAS No.: 3121287-19-9
Formula: C₄₇H₅₁ClF₂N₁₀O₆
Molecular Weight:925.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC BCL6 Degrader-4 Chemical Structure

CAS No.: 3121287-19-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All PROTACs Isoforms :

In Vitro

PROTAC BCL6 Degrader-4 (compound 12) potently degrades BCL6 in T47D cells with a DC₅₀ of <5 nM and achieves ≥70% maximum degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3121287-19-9
Molecular Weight 925.42
Formula C₄₇H₅₁ClF₂N₁₀O₆
SMILES

CN1C(C2=C(C3=C1C=CC(NC4=NC(N5CCC(CC5)O[C@H]6C[C@@H](C6)N7CCC(CC7)C8=CC9=C(C(N(N=C9)C%10CCC(NC%10=O)=O)=O)C=C8)=NC=C4Cl)=C3)N[C@H](C(F)(CO2)F)C%11CC%11)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Renner AC, et al. Degradation and Detection: Integrating BCL6 Targeted Protein Degradation with Biomarker-Guided BET Inhibition in Cancer. ACS Med Chem Lett. 2026 May 26;17(6):1246-1248. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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