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Cat. No.: HY-184007

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PROTAC BCL6 Degrader-4

PROTAC BCL6 Degrader-4 is a potent PROTAC BCL6 degrader. PROTAC BCL6 Degrader-4 recruits CRBN E3 ligase machinery to promote ubiquitination and proteasomal degradation of BCL6. PROTAC BCL6 Degrader-4 can be used for the research of diffuse large B-cell lymphoma and related hematological malignancies.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3121287-19-9
화학식: C₄₇H₅₁ClF₂N₁₀O₆
분자량:925.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PROTAC BCL6 Degrader-4 Chemical Structure

CAS No.: 3121287-19-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

All PROTACs Isoforms :

In Vitro

PROTAC BCL6 Degrader-4 (compound 12) potently degrades BCL6 in T47D cells with a DC₅₀ of <5 nM and achieves ≥70% maximum degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3121287-19-9
분자량 925.42
화학식 C₄₇H₅₁ClF₂N₁₀O₆
SMILES

CN1C(C2=C(C3=C1C=CC(NC4=NC(N5CCC(CC5)O[C@H]6C[C@@H](C6)N7CCC(CC7)C8=CC9=C(C(N(N=C9)C%10CCC(NC%10=O)=O)=O)C=C8)=NC=C4Cl)=C3)N[C@H](C(F)(CO2)F)C%11CC%11)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Renner AC, et al. Degradation and Detection: Integrating BCL6 Targeted Protein Degradation with Biomarker-Guided BET Inhibition in Cancer. ACS Med Chem Lett. 2026 May 26;17(6):1246-1248. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
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- In Vitro
Chemical Information
순도&문서
References

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PROTAC BCL6 Degrader-4

All PROTACs Isoforms

Biological Activity

제품 설명

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

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PROTAC BCL6 Degrader-4

All PROTACs Isoforms

Biological Activity

제품 설명

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs