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Cat. No.: HY-177755

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BCL6-IN-10

BCL6-IN-10 is a molecular glue inhibitor targeting the BCL6 BTB domain with an IC₅₀ of 4 nM. BCL6-IN-10 blocks the interaction between BCL6 and transcriptional co-repressors, and induces partial degradation of BCL6 via the ubiquitin-proteasome pathway, thereby de-repressing BCL6 target genes and inhibiting cancer cell proliferation. BCL6-IN-10 can be used in the research of diffuse large B-cell lymphoma.

For research use only. We do not sell to patients.

CAS No.: 2230406-52-5
Formula: C₂₂H₂₃ClF₂N₆O₃
Molecular Weight:492.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BCL6-IN-10 Chemical Structure

CAS No.: 2230406-52-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

BCL6-IN-10 (compound 6) (5 μM; 90 min) acts as a partial BCL6 degrader in SU-DHL-4 diffuse large B-cell lymphoma (DLBCL) cells^[1].
BCL6-IN-10 induces the derepression of BCL6 target genes in SU-DHL-4 diffuse large B-cell lymphoma (DLBCL) cells^[1].
BCL6-IN-10 potently inhibits the interaction between the BCL6 BTB domain and corepressor peptides, with an IC₅₀ of 4 nM ^[1].
BCL6-IN-10 inhibits the BCL6-corepressor interaction in mammalian cells with an IC₅₀ of 128 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2230406-52-5
Molecular Weight 492.91
Formula C₂₂H₂₃ClF₂N₆O₃
SMILES

CNC(COC1=CC2=CC(NC3=NC(N4CCC(F)(CC4)F)=NC=C3Cl)=CC=C2N(C1=O)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20(12):2860-2875. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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