1. PROTAC Apoptosis
  2. PROTACs Bcl-2 Family
  3. BCL6 PROTAC 1

BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) PROTAC. BCL6 PROTAC 1 inhibits BCL6 cell reporter with an IC50 value of 8.8 µM. BCL6 PROTAC 1 significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines. BCL6 PROTAC 1 can be used in tumor related research.

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BCL6 PROTAC 1 Chemical Structure

BCL6 PROTAC 1 Chemical Structure

CAS No. : 2257479-54-0

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Description

BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) PROTAC. BCL6 PROTAC 1 inhibits BCL6 cell reporter with an IC50 value of 8.8 µM. BCL6 PROTAC 1 significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines. BCL6 PROTAC 1 can be used in tumor related research[1].

IC50 & Target

B-cell lymphoma 6, BCL6[1]

In Vitro

BCL6 PROTAC 1 (Compound 15)(0.0001-10 µM; 1-72 h) degrades B-cell lymphoma 6 (BCL6) with dose-dependent manner in OCI-Ly1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: OCI-Ly1 cells.
Concentration: 1 µM.
Incubation Time: 16 d.
Result: Had no effect on cell viability.

Western Blot Analysis[1]

Cell Line: OCI-Ly1 cells.
Concentration: 0.0001, 0.001, 0.01, 0.1, 0.2, 1, 3, 5 and 10 µM.
Incubation Time: 1, 2, 4, 6, 8, 10, 24, 48, 72 h.
Result: Degraded BCL6.
Molecular Weight

946.40

Formula

C45H52ClN9O12

CAS No.
SMILES

O=C(N1)C(N2C(C(C(OCCOCCOCCCNC(CCC(N3CCN(C4=NC=C(Cl)C(N5)=N4)[C@@H](COCCOC6=CC5=CC(CC7)=C6N(C)C7=O)C3)=O)=O)=CC=C8)=C8C2=O)=O)CCC1=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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BCL6 PROTAC 1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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BCL6 PROTAC 1
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HY-122829
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