PROTAC BCL6 Degrader-2
PROTAC BCL6 Degrader-2 (Compound A19) is an orally active, selective BCL6 PROTAC degrader (DC50s: 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells). PROTAC BCL6 Degrader-2 promotes the ubiquitination and degradation of BCL6. PROTAC BCL6 Degrader-2 exhibits anticancer activity against BCL6-dependent diffuse large B-cell lymphoma (Pink: BCL6 ligand (HY-178804); Blue: E3 ligase ligand (HY-W087383); E3 ligase ligand + linker (HY-W998306)).
(Pink: BCL6 ligand (HY-178804); Blue: Cereblon ligand (HY-W087383); Black: linker).
For research use only. We do not sell to patients.
- Formula: C46H52ClN11O8
- Molecular Weight:922.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
DC50: 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells (BCL6)[1]
Chemical Information
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Molecular Weight 922.43
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Formula C46H52ClN11O8
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SMILES
O=C1N(C(C2=CC(N3CCN(CC3)CC4CCN(CC4)C(C5CCN(C6=NC(NC7=CC(C=C8OCC(NC)=O)=C(C=C7)N(C)C8=O)=C(C=N6)Cl)CC5)=O)=CC=C21)=O)C9CCC(NC9=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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