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Cat. No.: HY-178803

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PROTAC BCL6 Degrader-2

Name: PROTAC BCL6 Degrader-2
Brand: MedChemExpress
SKU: HY-178803
Price: 520.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

PROTAC BCL6 Degrader-2 (Compound A19) is an orally active, selective BCL6 PROTAC degrader (DC₅₀s: 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells). PROTAC BCL6 Degrader-2 promotes the ubiquitination and degradation of BCL6. PROTAC BCL6 Degrader-2 exhibits anticancer activity against BCL6-dependent diffuse large B-cell lymphoma (Pink: BCL6 ligand (HY-178804); Blue: E3 ligase ligand (HY-W087383); E3 ligase ligand + linker (HY-W998306)).
(Pink: BCL6 ligand (HY-178804); Blue: Cereblon ligand (HY-W087383); Black: linker).

For research use only. We do not sell to patients.

Purity: 99.70%
Formula: C₄₆H₅₂ClN₁₁O₈
Molecular Weight:922.43

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PROTAC BCL6 Degrader-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

PROTAC BCL6 Degrader-2 (Compound A19) is an orally active, selective BCL6 PROTAC degrader (DC₅₀s: 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells). PROTAC BCL6 Degrader-2 promotes the ubiquitination and degradation of BCL6. PROTAC BCL6 Degrader-2 exhibits anticancer activity against BCL6-dependent diffuse large B-cell lymphoma (Pink: BCL6 ligand (HY-178804); Blue: E3 ligase ligand (HY-W087383); E3 ligase ligand + linker (HY-W998306))^[1]. (Pink: BCL6 ligand (HY-178804); Blue: Cereblon ligand (HY-W087383); Black: linker).

IC₅₀ & Target

DC₅₀: 34 pM in OCI-LY1 cells and 0.45 nM in HEK293T cells (BCL6)^[1]

All PROTACs Isoforms :

Chemical Information

Appearance Solid
Molecular Weight 922.43
Formula C₄₆H₅₂ClN₁₁O₈
Color Light yellow to yellow
SMILES

O=C1N(C(C2=CC(N3CCN(CC3)CC4CCN(CC4)C(C5CCN(C6=NC(NC7=CC(C=C8OCC(NC)=O)=C(C=C7)N(C)C8=O)=C(C=N6)Cl)CC5)=O)=CC=C21)=O)C9CCC(NC9=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yu X, et al. Discovery of a Selective and Potent BCL6 PROTAC with Efficacious Antiproliferative Activity for the Treatment of Diffuse Large B-Cell Lymphoma. J Med Chem. 2025 Oct 9;68(19):20180-20206. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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PROTAC BCL6 Degrader-2

All PROTACs Isoforms