ZD-1-186
ZD-1-186 is a nondegradative molecular glue that potently suppresses MYC and robustly induces CDKN1A (p21) in diffuse large B-cell lymphoma cells. ZD-1-186 brings together BCL6 with BRD9, a noncanonical BAF complex bromodomain protein implicated in maintaining MYC transcriptional output in specific lymphoma contexts. ZD-1-186 can be used for targeted transcriptional rewiring research.
For research use only. We do not sell to patients.
- Formula: C35H37ClFN9O5S
- Molecular Weight:750.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Molecular Weight 750.24
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Formula C35H37ClFN9O5S
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SMILES
CNC(COC1=CC2=C(N(C)C1=O)C=CC(NC3=C(C=NC(N4CCN(C(/C=C/C(NC5=CC=C(C(F)=C5)N6CCSCC6)=O)=O)CC4)=N3)Cl)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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