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Cat. No.: HY-143653

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BCL6-IN-6

고객리뷰

Based on 1 Customer Validation

BCL6-IN-6 is a potent inhibitor of transcriptional repressor B-cell lymphoma 6 (BCL6). BCL6-IN-6 significantly blocks the interaction of BCL6 with its corepressors and reactivates BCL6 target genes in a dose-dependent manner. BCL6-IN-6 has the potential for the research of diffuse large B-cell lymphoma (DLBCL).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.10%
CAS No.: 2408882-54-0
화학식: C₂₇H₃₁FN₆O₂S
분자량:522.64

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

BCL6-IN-6 Chemical Structure

CAS No.: 2408882-54-0

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

BCL6^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
DOHH-2	IC₅₀	1 μM Compound: 28	Antiproliferative activity against BCL-6 dependent human DOHH-2 cells by CCK-8 assay Antiproliferative activity against BCL-6 dependent human DOHH-2 cells by CCK-8 assay	[PMID: 33844535]
DOHH-2	IC₅₀	1.21 μM Compound: 14j	Antiproliferative activity against human DOHH2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human DOHH2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
Farage	IC₅₀	1 μM Compound: 28	Antiproliferative activity against BCL-6 dependent human Farage cells by CCK-8 assay Antiproliferative activity against BCL-6 dependent human Farage cells by CCK-8 assay	[PMID: 33844535]
Farage	IC₅₀	1.26 μM Compound: 14j	Antiproliferative activity against human Farage cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human Farage cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
L02	IC₅₀	13.1 μM Compound: 14j	Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
NCM460	IC₅₀	32.4 μM Compound: 14j	Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
OCI-Ly7	IC₅₀	1 μM Compound: 28	Antiproliferative activity against BCL-6 dependent human OCILY7 cells by CCK-8 assay Antiproliferative activity against BCL-6 dependent human OCILY7 cells by CCK-8 assay	[PMID: 33844535]
OCI-Ly7	IC₅₀	1.62 μM Compound: 14j	Antiproliferative activity against human OCI-LY7 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human OCI-LY7 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
PNT1A	IC₅₀	8.13 μM Compound: 14j	Cytotoxicity against human PNT1A cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Cytotoxicity against human PNT1A cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
SUD4	IC₅₀	0.92 μM Compound: 14j	Antiproliferative activity against human SUDHL4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human SUDHL4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
SUD4	IC₅₀	1 μM Compound: 28	Antiproliferative activity against BCL-6 dependent human SU-DHL-4 cells by CCK-8 assay Antiproliferative activity against BCL-6 dependent human SU-DHL-4 cells by CCK-8 assay	[PMID: 33844535]
Toledo	IC₅₀	3.25 μM Compound: 14j	Antiproliferative activity against BCL6-negative human Toledo cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against BCL6-negative human Toledo cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
Toledo	IC₅₀	3.3 μM Compound: 28	Antiproliferative activity against BCL-6 independent human Toledo cells by CCK-8 assay Antiproliferative activity against BCL-6 independent human Toledo cells by CCK-8 assay	[PMID: 33844535]

Chemical Information

CAS No. 2408882-54-0
Appearance Solid
분자량 522.64
화학식 C₂₇H₃₁FN₆O₂S
Color Light yellow to yellow
SMILES

O=C(C1=CC=C(C2=CCCC2)S1)NC3=CC=C(NC4=NC(N5C[C@@H](C)N[C@@H](C)C5)=NC=C4F)C=C3OC
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : ≥ 4 mg/mL (7.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9134 mL

9.5668 mL

19.1336 mL

5 mM

0.3827 mL

1.9134 mL

3.8267 mL

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guo W, et al. Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of N-Phenyl-4-pyrimidinamine Derivatives Bearing Potent Activities against Tumor Growth. J Med Chem. 2020;63(2):676-695. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9134 mL	9.5668 mL	19.1336 mL	47.8341 mL
DMSO	5 mM	0.3827 mL	1.9134 mL	3.8267 mL	9.5668 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
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수량:
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상품명:
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BCL6-IN-6

Anti-Blood Cancer Compound Library

Transcription Factor-Targeted Library

Heterocyclic Compound Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Immunology/Inflammation Compound Library

Anti-Cancer Compound Library

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

BCL6-IN-6

Anti-Blood Cancer Compound Library

Transcription Factor-Targeted Library

Heterocyclic Compound Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Immunology/Inflammation Compound Library

Anti-Cancer Compound Library

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

BCL6-IN-6 Related Classifications

HY-143653 Related Classifications