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Cat. No.: HY-122476

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Leupeptin acid

Leupeptin acid is a peptide byproduct present in the fermentation product of Streptomyces roseus MA839-A1, and also an intermediate in leupeptin biosynthesis. Leupeptin acid serves as a substrate for leupeptin acid reductase to generate Leupeptin (HY-18234).

For research use only. We do not sell to patients.

CAS No.: 24125-28-8
Formula: C₂₀H₃₈N₆O₅
Molecular Weight:442.55

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Please store the product under the recommended conditions in the Certificate of Analysis.

Leupeptin acid Chemical Structure

CAS No.: 24125-28-8

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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Leupeptin acid is reduced to Leupeptin (HY-18234) by solubilized leupeptin acid reductase from Streptomyces roseus MA839-A1 in an ATP- and NADPH-dependent manner; the enzyme has K_m values of 4.2 × 10^-5 M for ATP and 1.3 × 10^-6 M for NADPH, and is strongly suppressed by leupeptin and antipain rather than elastatinal^[2].
Leupeptin acid is biosynthesized as an intermediate to form leupeptin by the combined leucine acyltransferase and leupeptin acid synthetase-reductase complex from Streptomyces roseus MA839-A1 using acetyl-CoA, L-leucine (HY-N0486) and L-arginine (HY-N0455) as substrates^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 24125-28-8
Molecular Weight 442.55
Formula C₂₀H₃₈N₆O₅
SMILES

N=C(NCCC[C@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)C(O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Suzukake K, et al. Biosynthesis of Leupeptin. II. Purification and Properties of Leupeptin Acid Synthetase. The Journal of Antibiotics, 1979, 32(5): 523-529.

[2]. Suzukake K, et al. Purification and properties of an enzyme reducing leupeptin acid to leupeptin. Biochimica et biophysica acta. 1981 Oct 13;661(2):175-81. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Purity & Documentation
References

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Leupeptin acid

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Leupeptin acid Related Classifications

HY-122476 Related Classifications