Cat. No.: HY-152852

Mefatinib free base

(Synonyms: Mifanertinib)

Customer Review

Based on 1 Customer Validation

Mefatinib free base (Mifanertinib) is an orally active EGFR and HER2 kinase inhibitor with IC₅₀ values of 0.4 nM and 11.7 nM, respectively. Mefatinib free base inhibits tumor growth in mouse models of lung cancer xenografts that overexpress EGFR/HER2, carry EGFR mutations, or carry Erlotinib (HY-50896)-resistant EGFR double mutations. Mefatinib free base can be used for the research of advanced EGFR-mutant non-small cell lung cancer.

For research use only. We do not sell to patients.

Purity: 99.40%
CAS No.: 1639014-72-4
Formula: C₂₁H₁₉ClF₃N₅O₂
Molecular Weight:465.86

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Mefatinib free base Chemical Structure

CAS No.: 1639014-72-4

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

EGFR

0.4 nM (IC₅₀)

HER2

11.7 nM (IC₅₀)

All EGFR Isoforms :

In Vivo

Mefatinib free base exhibits potent anti-tumor activity in a nude mouse xenograft model of erlotinib (HY-50896)-resistant EGFR^L858R/T790M-mutant non-small cell lung cancer^[1].
Mefatinib (0.2 mg/kg) free base achieves 99.6% tumor growth inhibition in a nude mouse xenograft model of human lung adenocarcinoma HCC827^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1639014-72-4
Appearance Solid
Molecular Weight 465.86
Formula C₂₁H₁₉ClF₃N₅O₂
Color White to off-white
SMILES

O=C(NC1=CC2=C(NC3=CC=C(C(Cl)=C3)F)N=CN=C2C=C1OC(F)F)/C=C/CN(C)C
Synonyms

Mifanertinib
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (107.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1466 mL

10.7328 mL

21.4657 mL

5 mM

0.4293 mL

2.1466 mL

4.2931 mL

10 mM

0.2147 mL

1.0733 mL

2.1466 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang P, et al. Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer: a phase Ib/II efficacy and biomarker study. Signal transduction and targeted therapy. 2021 Nov 01;6(1):374. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1466 mL	10.7328 mL	21.4657 mL	53.6642 mL
	5 mM	0.4293 mL	2.1466 mL	4.2931 mL	10.7328 mL
	10 mM	0.2147 mL	1.0733 mL	2.1466 mL	5.3664 mL
	15 mM	0.1431 mL	0.7155 mL	1.4310 mL	3.5776 mL
	20 mM	0.1073 mL	0.5366 mL	1.0733 mL	2.6832 mL
	25 mM	0.0859 mL	0.4293 mL	0.8586 mL	2.1466 mL
	30 mM	0.0716 mL	0.3578 mL	0.7155 mL	1.7888 mL
	40 mM	0.0537 mL	0.2683 mL	0.5366 mL	1.3416 mL
	50 mM	0.0429 mL	0.2147 mL	0.4293 mL	1.0733 mL
	60 mM	0.0358 mL	0.1789 mL	0.3578 mL	0.8944 mL
	80 mM	0.0268 mL	0.1342 mL	0.2683 mL	0.6708 mL
	100 mM	0.0215 mL	0.1073 mL	0.2147 mL	0.5366 mL

Keywords

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Mefatinib free base

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Covalent Screening Library

Differentiation Inducing Compound Library

Orally Active Compound Library

Anti-Hepatitis C Virus Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cysteine Targeted Covalent Library

Cytokine Inhibitors Library

Anti-Drug-Resistant Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

All EGFR Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Mefatinib free base Related Classifications

HY-152852 Related Classifications