MnTBAP chloride
Based on 6 publication(s) in Google Scholar
MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 55266-18-7
- Formula: C48H28ClMnN4O8
- Molecular Weight:879.15
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Publications Citing Use of MedChemExpress (MCE) MnTBAP chloride
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Histological Imaging/Staining
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Biological Activity
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NFκB |
MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs)[1].
MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice with 5/6 nephrectomy (Nx)[1]
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Dosage:10 mg/kg
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Administration:IP; three times per week for twelve weeks
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Result:Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
Chemical Information
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CAS No. 55266-18-7
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Appearance Solid
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Molecular Weight 879.15
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Formula C48H28ClMnN4O8
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Color Brown to black
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SMILES
[Cl-][Mn+3]12([N](C(C=C3)=C4C(C=C5)=CC=C5C(O)=O)=C3C(C(C=C6)=CC=C6C(O)=O)=C7C=C8)[N-]7C8=C(C(C=C9)=CC=C9C(O)=O)C%10=[N]1C(C=C%10)=C(C(C=C%11)=CC=C%11C(O)=O)C%12=CC=C4[N-]2%12
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (6)
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Journal Impact Factor
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Most Recent
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Redox Biol
Endothelial Lon protease 1 facilitates the redox balance to prevent glomerulosclerosis by acting on superoxide dismutase 2 ubiquitination. [Abstract]2025 Dec:88:103929. PMID: 41275592 -
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J Immunother Cancer
Macrophage NLRP3 activation and IL-1β release drive osimertinib-induced antitumor immunity. [Abstract]2025 Oct 5;13(10):e012182. PMID: 41052880 -
Free Radic Biol Med
A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial ROS-mediated ferroptosis. [Abstract]2023 Jan:194:84-98. PMID: 36403736
MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2023 Jan:194:84-98. [Abstract]
The decreased protein expression levels of the ferroptosis repressors NRF2, SLC7A11, and GPX4 after cisplatin stimuli are rescued by 84-B10 (40 µM), MnTBAP (80 µM), and Lipro-1 (2 µM) pretreat for 2 h, in TKPT cells.
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Biochem Pharmacol
MnTBAP attenuates pulmonary hypertension-induced right ventricular dysfunction and remodeling by modulating the CaMKIIδ-SERCA2a signaling pathway. [Abstract]2026 Mar 21:249:117920. PMID: 41871719
MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 Mar 21:249:117920. [Abstract]
Pulmonary arteriole morphology and wall area were estimated by H&E staining treated with MnTBAP (10 mg/kg, i.p.).
MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 Mar 21:249:117920. [Abstract]
Myocardial cell size was measured by WGA staining treated with MnTBAP (10 mg/kg, i.p.).
MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 Mar 21:249:117920. [Abstract]
MnTBAP (10 mg/kg, i.p.) treatment partially prevented the upregulation of the mRNA expression of inflammation.
MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 Mar 21:249:117920. [Abstract]
Immunofluorescence staining of myocardial sections for p-CaMKIIδ Thr287 (red) and DAPI (blue) is shown treated with MnTBAP (10 mg/kg, i.p.).
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J Inorg Biochem
Insight into the interaction of heme with human calcitonin (hCT) and its inhibitory effect on hCT aggregation. [Abstract]2026 Jul:280:113319. PMID: 41911648
Solvent & Solubility
1 M NaOH : 100 mg/mL (113.75 mM; Need ultrasonic)
0.5 M NaOH : 20 mg/mL (22.75 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (283 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Jing Yu, et al. MnTBAP Therapy Attenuates Renal Fibrosis in Mice With 5/6 Nephrectomy. Oxid Med Cell Longev. 2016;2016:7496930. [Content Brief]
[2]. Qian Zhou, et al. MnTBAP Increases BMPR-II Expression in Endothelial Cells and Attenuates Vascular Inflammation. Vascul Pharmacol. 2016 Sep;84:67-73. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.5 M NaOH / 1 M NaOH | 1 mM | 1.1375 mL | 5.6873 mL | 11.3746 mL | 28.4366 mL |
| 5 mM | 0.2275 mL | 1.1375 mL | 2.2749 mL | 5.6873 mL | |
| 10 mM | 0.1137 mL | 0.5687 mL | 1.1375 mL | 2.8437 mL | |
| 15 mM | 0.0758 mL | 0.3792 mL | 0.7583 mL | 1.8958 mL | |
| 20 mM | 0.0569 mL | 0.2844 mL | 0.5687 mL | 1.4218 mL | |
| 1 M NaOH | 25 mM | 0.0455 mL | 0.2275 mL | 0.4550 mL | 1.1375 mL |
| 30 mM | 0.0379 mL | 0.1896 mL | 0.3792 mL | 0.9479 mL | |
| 40 mM | 0.0284 mL | 0.1422 mL | 0.2844 mL | 0.7109 mL | |
| 50 mM | 0.0227 mL | 0.1137 mL | 0.2275 mL | 0.5687 mL | |
| 60 mM | 0.0190 mL | 0.0948 mL | 0.1896 mL | 0.4739 mL | |
| 80 mM | 0.0142 mL | 0.0711 mL | 0.1422 mL | 0.3555 mL | |
| 100 mM | 0.0114 mL | 0.0569 mL | 0.1137 mL | 0.2844 mL |
MnTBAP chloride Related Classifications
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