2-Chlorobenzimidazole
Based on 1 Customer Validation
2-Chlorobenzimidazole is a pharmaceutical intermediate used in the synthesis of a series of derivatives with anti-human cytomegalovirus (HCMV) activity. 2-Chlorobenzimidazole can be used to form metal complexes (cobalt, copper, and zinc), with zinc complexes exhibiting significant anticancer activity.
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- Pureté: 98.0%
- CAS No.: 4857-06-1
- Formule: C7H5ClN2
- Masse moléculaire:152.58
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Chemical Information
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CAS No. 4857-06-1
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Appearance Solid
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Masse moléculaire 152.58
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Formule C7H5ClN2
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Color White to off-white
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SMILES
ClC1=NC2=CC=CC=C2N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (655.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.38 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Zou R, Drach JC, Townsend LB. Design, synthesis, and antiviral evaluation of 2-chloro-5,6-dihalo-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections. J Med Chem. 1997 Feb 28;40(5):811-8. [Content Brief]
[2]. Sánchez-Guadarrama O, et al. Cytotoxic activity, X-ray crystal structures and spectroscopic characterization of cobalt(II), copper(II) and zinc(II) coordination compounds with 2-substituted benzimidazoles. J Inorg Biochem. 2009 Sep;103(9):1204-13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 6.5539 mL | 32.7697 mL | 65.5394 mL | 163.8485 mL |
| 5 mM | 1.3108 mL | 6.5539 mL | 13.1079 mL | 32.7697 mL | |
| 10 mM | 0.6554 mL | 3.2770 mL | 6.5539 mL | 16.3848 mL | |
| 15 mM | 0.4369 mL | 2.1846 mL | 4.3693 mL | 10.9232 mL | |
| 20 mM | 0.3277 mL | 1.6385 mL | 3.2770 mL | 8.1924 mL | |
| 25 mM | 0.2622 mL | 1.3108 mL | 2.6216 mL | 6.5539 mL | |
| 30 mM | 0.2185 mL | 1.0923 mL | 2.1846 mL | 5.4616 mL | |
| 40 mM | 0.1638 mL | 0.8192 mL | 1.6385 mL | 4.0962 mL | |
| 50 mM | 0.1311 mL | 0.6554 mL | 1.3108 mL | 3.2770 mL | |
| 60 mM | 0.1092 mL | 0.5462 mL | 1.0923 mL | 2.7308 mL | |
| 80 mM | 0.0819 mL | 0.4096 mL | 0.8192 mL | 2.0481 mL | |
| 100 mM | 0.0655 mL | 0.3277 mL | 0.6554 mL | 1.6385 mL |
2-Chlorobenzimidazole Related Classifications
HY-W015575 Related Classifications
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