5-Formyl-dCTP lithium
5-Formyl-dCTP (5-Formyl-deoxycytidine) lithium is a DCTPP1 substrate. 5-Formyl-dCTP lithium acts as a mutagen/epigenetic disruptor via DNA polymerase incorporation, mutagenic mispairings, and disturbed epigenetic programming. 5-Formyl-dCTP lithium can be used for research on genotoxicity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2409156-19-8
- Formule: C10H12Li4N3O14P3
- Masse moléculaire:518.90
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis
More
Activité biologique
5-Formyl-dCTP lithium exhibits enriched, specific binding to Con A (Kd,eff = 20 nM) with minimal binding to PSA (Kd,eff > 1 μM) after three rounds of two-color click-PD screening[1].
5-Formyl-dCTP lithium (10-250 μM) is hydrolysed by purified recombinant human DCTPP1 with high efficiency, exhibiting a Km of 9.2 μM, the lowest substrate affinity reported for the enzyme, and a specificity constant of 322,000/M·s[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2409156-19-8
-
Masse moléculaire 518.90
-
Formule C10H12Li4N3O14P3
-
SMILES
O=CC1=CN([C@@H](C[C@@H]2O)O[C@@H]2COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O)C(N=C1N)=O
-
Synonyms
5-Formyl-deoxycytidine lithium
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Gordon CKL, et al. Click-Particle Display for Base-Modified Aptamer Discovery. ACS Chem Biol. 2019;14(12):2652-2662. [Content Brief]
[2]. Requena CE, et al. The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells. Biochem J. 2014;459(1):171-180. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-Formyl-dCTP lithium Related Classifications
HY-160596 Related Classifications
Powered by Bioz