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Cat. No.: HY-111748

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RORγt Inverse agonist 2

RORγt Inverse agonist 2 is a selective, orally active RORγt inverse agonist with an EC₅₀ of 119 nM.

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CAS No.: 1801197-92-1
Formule: C₂₇H₂₅F₈NO₅S
Masse moléculaire:627.54

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

RORγt Inverse agonist 2 Chemical Structure

CAS No.: 1801197-92-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

RORγt Inverse agonist 2 is a selective, orally active RORγt inverse agonist with an EC₅₀ of 119 nM^[1].

IC₅₀ & Target

EC50: 119 nM (RORγt)^[1]

Voir tous les produits spécifiques à Isoform ROR :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	>50000 nM Compound: 26	Transactivation of PXR in human HepG2 cells Transactivation of PXR in human HepG2 cells	[PMID: 30891142]
Jurkat	EC₅₀	>40 μM Compound: 2	Inverse agonist activity at human Gal4-fused RORalpha LBD (272 to 556 residues) expressed in human Jurkat cells measured after 18 hrs by steady-glo luciferase reporter gene assay Inverse agonist activity at human Gal4-fused RORalpha LBD (272 to 556 residues) expressed in human Jurkat cells measured after 18 hrs by steady-glo luciferase reporter gene assay	[PMID: 31257087]
Jurkat	EC₅₀	>40 μM Compound: 2	Inverse agonist activity at human Gal4-fused RORbeta LBD (200 to 559 residues) expressed in human Jurkat cells measured after 18 hrs by steady-glo luciferase reporter gene assay Inverse agonist activity at human Gal4-fused RORbeta LBD (200 to 559 residues) expressed in human Jurkat cells measured after 18 hrs by steady-glo luciferase reporter gene assay	[PMID: 31257087]

In Vitro

RORγt Inverse agonist 2 (Compound 26) is inactive against RORα and RORβ in either inverse agonist or agonist mode (>40 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1801197-92-1
Masse moléculaire 627.54
Formule C₂₇H₂₅F₈NO₅S
SMILES

FC(C(F)(F)F)(C(F)(F)F)C1=CC=C([C@]2(CN(C([C@@H]3CC[C@@H](C(O)=O)CC3)=O)CC2)S(C4=CC=C(F)C=C4)(=O)=O)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Duan JJ, et al. Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists. ACS Med Chem Lett. 2019 Feb 26;10(3):367-373. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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RORγt Inverse agonist 2

Voir tous les produits spécifiques à Isoform ROR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

RORγt Inverse agonist 2 Related Classifications

HY-111748 Related Classifications