Chlorpheniramine-d6
Chlorpheniramine-d6 (Chlorphenamine-d6) is deuterium labeled Chlorpheniramine. Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research.
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- CAS No.: 1185054-60-7
- Formule: C16H13D6ClN2
- Masse moléculaire:280.83
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1185054-60-7
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Unlabeled Cas 132-22-9
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Masse moléculaire 280.83
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Formule C16H13D6ClN2
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SMILES
[2H]C([2H])([2H])N(C([2H])([2H])[2H])CCC(C1=CC=CC=N1)C2=CC=C(C=C2)Cl
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Synonyms
Chlorphenamine-d6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Jiwon Kim, etal. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128. [Content Brief]
[3]. Kyung-Jin Jung, etal. Enhancement of B cell and monocyte populations in rats exposed to chlorpheniramine. Arch Pharm Res. 2012 Dec;35(12):2183-9. [Content Brief]
[4]. Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471(3): p. 223-8. [Content Brief]
[5]. Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51(11): p. 4133-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chlorpheniramine-d6 Related Classifications
HY-B0286S2 Related Classifications
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