132-22-9
132-22-9
Chemical Structure
Chlorpheniramine
Synonym(s): Chlorphenamine
- CAS No.: 132-22-9
- Formula:C16H19ClN2
- Molecular Weight:274.79
IUPAC Name: 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
InChIKey: SOYKEARSMXGVTM-UHFFFAOYSA-N
SMILES: CN(C)CCC(C1=CC=C(Cl)C=C1)C2=CC=CC=N2
Biological Activity: Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Chlorpheniramine | 99.86% | Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Chlorpheniramine (Standard) | ≥98% | Chlorpheniramine (Standard) is the analytical standard of Chlorpheniramine. This product is intended for research and analytical applications. Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Chlorpheniramine-d4 | Chlorpheniramine-d4 (Chlorphenamine-d4) is deuterium labeled Chlorpheniramine. Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Chlorpheniramine-d6 | Chlorpheniramine-d6 (Chlorphenamine-d6) is deuterium labeled Chlorpheniramine. Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Dexchlorpheniramine | Dexchlorpheniramine is an potent and blood-brain barrier (BBB) penetrant histamine 1 (H1) receptor antagonist with anticholinergic properties. Dexchlorpheniramine can be used for researching allergies. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(R)-(-)-Chlorpheniramine maleate | (R)-(-)-Chlorpheniramine maleate is an enantiomer of Chlorpheniramine maleate (HY-B0286A). Chlorpheniramine maleate is a H1 antihistamines. (R)-(-)-Chlorpheniramine maleate can be used for allergic diseases such as rhinitis and urticaria research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(-)-Brompheniramine | 99.82% | (-)-Brompheniramine is a H1 receptor antagonist with antiallergic activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Dexbrompheniramine | 99.93% | Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine can be used in the research of chronic cough and related pathological mechanisms. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Chlorpheniramine maleate | 99.67% | Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Brompheniramine (Standard) | ≥98% | Brompheniramine (Standard) is the analytical standard of Brompheniramine. This product is intended for research and analytical applications. Brompheniramine ((±)-Brompheniramine) is a potent and orally active antihistamine of the alkylamine class. Brompheniramine is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Pheniramine | Pheniramine (Prophenpyridamine;Tripoton) is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cells apoptosis. Pheniramine is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Dexchlorpheniramine maleate (Standard) | ≥98% | Dexchlorpheniramine (maleate) (Standard) is the analytical standard of Dexchlorpheniramine (maleate). This product is intended for research and analytical applications. Dexchlorpheniramine maleate is an antihistamine with anticholinergic properties used in the study of allergic diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3-(4-Chlorophenyl)-N-methyl-3-(pyridin-2-yl)propan-1-amine (Standard) | ≥98% | Monodesmethylchlorpheniramine (Standard) is the analytical standard of Monodesmethylchlorpheniramine. This product is intended for research and analytical applications. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Jiwon Kim, etal. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128. [Content Brief]
- [2]. Kyung-Jin Jung, etal. Enhancement of B cell and monocyte populations in rats exposed to chlorpheniramine. Arch Pharm Res. 2012 Dec;35(12):2183-9. [Content Brief]
