Elliptinium acetate
Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used in cancer research, particularly in metastatic breast cancer.
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- CAS No.: 58337-35-2
- Formule: C20H20N2O3
- Masse moléculaire:336.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | ED50 |
60 ng/mL
Compound: 2-methyl-9-hydroxyellipticinium acetate
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Inhibitory activity against L1210 cell culture
Inhibitory activity against L1210 cell culture
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[PMID: 3746819] |
| L1210 | IC50 |
73 nM
Compound: elliptinium acetate
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In vitro cytotoxicity against L1210 (murine leukemia) cells.
In vitro cytotoxicity against L1210 (murine leukemia) cells.
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[PMID: 8057291] |
| MC-38 | IC50 |
38 nM
Compound: elliptinium acetate
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Tested for cytotoxicity against C38 cell lines measured by MAT assay
Tested for cytotoxicity against C38 cell lines measured by MAT assay
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[PMID: 8057291] |
| Tumor Cell line | GI50 |
>2.95 μM
Compound: 2
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GI50 was given In vitro as +50% percent growth (PG), measured as concentration of compound required to inhibit disease oriented human tumor cell line panels; Value ranges from 0.02->100
GI50 was given In vitro as +50% percent growth (PG), measured as concentration of compound required to inhibit disease oriented human tumor cell line panels; Value ranges from 0.02->100
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[PMID: 8027977] |
Elliptinium (0.35 µM; 1 h) (9-OH-NME3) shows highly stable covalent bonding to nucleic acids of L1210 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L1 210 cells
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Concentration:0.35 µM
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Incubation Time:1 h
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Result:Exhibited highly stable covalent bonding to DNA and RNA.
Showed no reversal of binding as cells went on replicating during a 40-h period.
Chemical Information
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CAS No. 58337-35-2
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Masse moléculaire 336.38
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Formule C20H20N2O3
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SMILES
O=C(C)[O-].OC1=CC=C2NC3=C(C)C4=C(C=[N+](C)C=C4)C(C)=C3C2=C1
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Synonyms
NSC 264137; Celiptium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Dugue B, et al. Covalent binding of elliptinium acetate (NSC 264137) to nucleic acids of L1210 cells in culture. Cancer Res. 1986 Aug;46(8):3828-33. [Content Brief]
[2]. Arteaga CL, et al. Elliptinium, a DNA intercalating agent with broad antitumor activity in a human tumor cloning system. Eur J Cancer Clin Oncol. 1987 Nov;23(11):1621-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Elliptinium acetate Related Classifications
HY-16189 Related Classifications
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