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Enfortumab

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Enfortumab is a humanized derived anti-Nectin-4 antibody that can be conjugated with the highly efficient microtubule disruptor MMAE (HY-15162) to generate the antibody drug conjugate (ADC) Enfortumab vedotin-ejfv (HY-P99016A). Enfortumab can be used for the study of locally advanced and metastatic urothelial carcinoma.

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  • Pureté: 99.90%
  • CAS No.: 1448664-46-7
  • Masse moléculaire:145.44 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Enfortumab
  • Experimental Validation Results for Enfortumab
  • Experimental Validation Results for Enfortumab
  • Enfortumab Chemical Structure
    Enfortumab Chemical Structure
CAS No.: 1448664-46-7
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human Nectin-4 His can bind Enfortumab. The EC50 for this effect is 3.846 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 MCF-7 cells with Enfortumab (HY-P99016, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Enfortumab Chemical Structure
    1/16
  • Enfortumab
  • Immobilized Human Nectin-4 His can bind Enfortumab. The EC50 for this effect is 3.846 ng/mL.
  • Flow cytometric analysis of 1X106 MCF-7 cells with Enfortumab (HY-P99016, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).