Fazadinium bromide
Fazadinium bromide (AH 8165 bromide) is a species-specific neuromuscular blocking agent that primarily targets the acetylcholine receptor (AChR) at the skeletal neuromuscular junction, blocking the receptor agonist binding site in a competitive and reversible manner. Fazadinium bromide induces sustained tetanic fade, and tetanic contractions are more sensitive than single twitches. Fazadinium bromide can be used in anesthesia and research related to neuromuscular transmission.
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- CAS No.: 49564-56-9
- Formule: C28H24Br2N6
- Masse moléculaire:604.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Fazadinium bromide (0.0625-4.0 mg/kg; i.v.) is four times more potent in anaesthetized rhesus monkeys than in cats, producing complete neuromuscular blockade at 0.5 mg/kg i.v. with a 1.5-5 minute onset and 36-minute mean recovery time, while inducing vagal blockade at near-paralyzing doses and sympathetic blockade at supramaximal doses[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 49564-56-9
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Masse moléculaire 604.34
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Formule C28H24Br2N6
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SMILES
CC1=C(N(C2=CC=CC=[N+]21)/N=N/N3C(C4=CC=CC=C4)=C([N+]5=CC=CC=C53)C)C6=CC=CC=C6.[Br-].[Br-]
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Synonyms
AH 8165 bromide
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fazadinium bromide Related Classifications
HY-127147 Related Classifications
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