Galcanezumab
Based on 1 publication(s) in Google Scholar
Galcanezumab (LY 2951742) is a humanized IgG4 monoclonal antibody against the CGRP ligand. Galcanezumab can be used for migraine or cluster headaches research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.00%
- CAS No.: 1578199-75-3
- Masse moléculaire:145.5 kDa
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Galcanezumab
More
Activité biologique
Human IgG4 kappa
Human
CALCA/CGRP
Galcanezumab inhibits human or rat CGRP-induced cAMP production in SK-N-MC cell with IC50s of 0.35 nM and 1.05 nM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Galcanezumab (4-16 mg/kg, sc, single dose) exhibits analgesic effect in Monoiodoacetate (HY-W017688)-induced mouse osteoarthritis pain models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ApoE-/- mouse model[2]
-
Dosage:30-50 mg/kg
-
Administration:sc, 2 doses, 50 mg/kg at the first week, 30 mg/kg at the second week
-
Result:Increased lipid deposition in the aortic root, increased the lesion area in the thoracic aorta.
-
Animal Model:Monoiodoacetate-induced mouse osteoarthritis pain models[3]
-
Dosage:4-16 mg/kg
-
Administration:sc, single dose
-
Result:Reduced mouse pain behavior.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG4 kappa
ELISA, FACS, Functional assay
-
Flow cytometric analysis of 1X106 A549 cells with Galcanezumab (HY-P99021, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.
Chemical Information
-
CAS No. 1578199-75-3
-
Appearance Liquid
-
Masse moléculaire 145.5 kDa
-
Color Colorless to light yellow
-
SMILES
[Galcanezumab]
-
Synonyms
LY 2951742
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Biosens Bioelectron
One-step ultra-rapid immunoassay of calcitonin gene-related peptide for migraine diagnosis. [Abstract]2025 Feb 15:270:116980. PMID: 39608279
Pureté et documentation
-
Fiche technique (261 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Références
[1]. Yvette N Lamb. Galcanezumab: First Global Approval. Drugs. 2018 Nov;78(16):1769-1775. [Content Brief]
[2]. Hashikawa-Hobara N, et al., Lack of alpha CGRP exacerbates the development of atherosclerosis in ApoE-knockout mice. Sci Rep. 2024 Aug 8;14(1):18377. [Content Brief]
[3]. Benschop RJ, et al., Development of a novel antibody to calcitonin gene-related peptide for the treatment of osteoarthritis-related pain. Osteoarthritis Cartilage. 2014 Apr;22(4):578-85. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Galcanezumab Related Classifications
HY-P99021 Related Classifications
Powered by Bioz