Wnt5a - wingless-type MMTV integration site family, member 5A Gene

Also Known as Wnt-5a; 8030457G12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22418

Summary

Enables Frizzled binding activity; protein domain specific binding activity; and receptor ligand activity. Involved in several processes, including Wnt signaling pathway; heart development; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; positive regulation of protein phosphorylation; and regulation of animal organ morphogenesis. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; limb; and sensory organ. Used to study Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A). [provided by Alliance of Genome Resources, Apr 2022]

Wnt5a Products (2)

mRNA Protein Name
NM_001256224.2 NP_001243153.1 protein Wnt-5a isoform 2 precursor
NM_009524.4 NP_033550.2 protein Wnt-5a isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables chemoattractant activity involved in axon guidance IDA
IDA: Inferred from direct assay
21106844 MGI
enables cytokine activity IDA
IDA: Inferred from direct assay
18986540 MGI
enables frizzled binding IDA
IDA: Inferred from direct assay
10893270 MGI
enables frizzled binding IPI
IPI: Inferred from physical interaction
10557084 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10866835 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
20093360 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
18351662 MGI
acts upstream of or within JNK cascade IDA
IDA: Inferred from direct assay
12839624 MGI
acts upstream of or within Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
11092808 MGI
involved in Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
23517308 MGI
involved in Wnt signaling pathway, calcium modulating pathway IDA
IDA: Inferred from direct assay
18174455 MGI
acts upstream of or within Wnt signaling pathway, calcium modulating pathway IMP
IMP: Inferred from mutant phenotype
18070933 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IDA
IDA: Inferred from direct assay
19056682 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IGI
IGI: Inferred from genetic interaction
17433286 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
17433286 MGI
involved in Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
21106844 MGI
involved in activation of GTPase activity IDA
IDA: Inferred from direct assay
18953410 MGI
involved in anterior/posterior axis specification, embryo IDA
IDA: Inferred from direct assay
9054360 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
15073149 MGI
involved in atrial septum development IGI
IGI: Inferred from genetic interaction
22569553 MGI
acts upstream of or within axis elongation IMP
IMP: Inferred from mutant phenotype
19100728 MGI
involved in axon guidance IDA
IDA: Inferred from direct assay
21483795 MGI
involved in axonogenesis IDA
IDA: Inferred from direct assay
23517308 MGI
acts upstream of or within canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17804636 MGI
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18929644 MGI
acts upstream of or within canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
16602827 MGI
acts upstream of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
12952940 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
17804636 MGI
acts upstream of or within cell migration IGI
IGI: Inferred from genetic interaction
17986005 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9160667 MGI
involved in cellular response to molecule of bacterial origin IDA
IDA: Inferred from direct assay
16601243 MGI
acts upstream of or within cervix development IMP
IMP: Inferred from mutant phenotype
15073149 MGI
involved in chemoattraction of serotonergic neuron axon IDA
IDA: Inferred from direct assay
21106844 MGI
involved in chemorepulsion of dopaminergic neuron axon IDA
IDA: Inferred from direct assay
21106844 MGI
acts upstream of or within cochlea morphogenesis IGI
IGI: Inferred from genetic interaction
17433286 MGI
acts upstream of or within cochlea morphogenesis IMP
IMP: Inferred from mutant phenotype
17433286 MGI
acts upstream of or within convergent extension IMP
IMP: Inferred from mutant phenotype
17433286 MGI
acts upstream of or within convergent extension involved in axis elongation IGI
IGI: Inferred from genetic interaction
25813538 MGI
acts upstream of or within convergent extension involved in axis elongation IMP
IMP: Inferred from mutant phenotype
25813538 MGI
acts upstream of or within convergent extension involved in organogenesis IGI
IGI: Inferred from genetic interaction
17433286 MGI
acts upstream of cytokine production IDA
IDA: Inferred from direct assay
23677472 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
24091014 MGI
acts upstream of or within development of primary male sexual characteristics IMP
IMP: Inferred from mutant phenotype
19100252 MGI
acts upstream of or within digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19300477 MGI
involved in dopaminergic neuron differentiation IDA
IDA: Inferred from direct assay
23324743 MGI
acts upstream of or within dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
18953410 MGI
involved in dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
23324743 MGI
acts upstream of or within dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
18953410 MGI
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
10021340 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
19795512 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
10021340 MGI
acts upstream of or within epithelial cell migration IMP
IMP: Inferred from mutant phenotype
16246260 MGI
acts upstream of epithelial cell proliferation IDA
IDA: Inferred from direct assay
17898001 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17898001 MGI
acts upstream of or within epithelial cell proliferation involved in mammary gland duct elongation IDA
IDA: Inferred from direct assay
17898001 MGI
acts upstream of or within establishment of epithelial cell apical/basal polarity IGI
IGI: Inferred from genetic interaction
25813538 MGI
acts upstream of or within establishment of planar polarity IMP
IMP: Inferred from mutant phenotype
18953410 MGI
acts upstream of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18351662 MGI
acts upstream of or within heart looping IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of or within hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
9160667 MGI
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
9160667 MGI
acts upstream of or within hindgut morphogenesis IMP
IMP: Inferred from mutant phenotype
18804104 MGI
acts upstream of or within hypophysis morphogenesis IMP
IMP: Inferred from mutant phenotype
15037319 MGI
acts upstream of or within inner ear morphogenesis IDA
IDA: Inferred from direct assay
18991062 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
18991062 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
27002738 MGI
acts upstream of or within lateral sprouting involved in mammary gland duct morphogenesis IDA
IDA: Inferred from direct assay
17898001 MGI
acts upstream of or within limb morphogenesis IMP
IMP: Inferred from mutant phenotype
19795512 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12142021 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
18804104 MGI
acts upstream of or within mammary gland branching involved in thelarche IDA
IDA: Inferred from direct assay
17898001 MGI
acts upstream of meiotic nuclear division IGI
IGI: Inferred from genetic interaction
20106871 MGI
involved in melanocyte proliferation IDA
IDA: Inferred from direct assay
23569434 MGI
acts upstream of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
19100728 MGI
acts upstream of or within mesenchymal-epithelial cell signaling IMP
IMP: Inferred from mutant phenotype
15073149 MGI
acts upstream of or within mesodermal to mesenchymal transition involved in gastrulation IGI
IGI: Inferred from genetic interaction
25813538 MGI
involved in midbrain development IDA
IDA: Inferred from direct assay
14557550 MGI
involved in midbrain development IGI
IGI: Inferred from genetic interaction
23324743 MGI
involved in midbrain dopaminergic neuron differentiation IDA
IDA: Inferred from direct assay
14557550 MGI
involved in midbrain dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
23324743 MGI
involved in midbrain dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
18953410 MGI
acts upstream of or within midgut development IMP
IMP: Inferred from mutant phenotype
19100728 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
15073149 MGI
acts upstream of or within negative regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
18351662 MGI
NOT involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
15748172 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17244647 MGI
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18986540 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
16602827 MGI
involved in negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
17244647 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
12952940 MGI
involved in negative regulation of cell proliferation in midbrain IMP
IMP: Inferred from mutant phenotype
18953410 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
17898001 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17898001 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18351662 MGI
involved in negative regulation of melanin biosynthetic process IDA
IDA: Inferred from direct assay
23569434 MGI
acts upstream of or within negative regulation of prostatic bud formation IMP
IMP: Inferred from mutant phenotype
18804104 MGI
involved in negative regulation of synapse assembly IDA
IDA: Inferred from direct assay
18986540 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
17433286 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
19795512 MGI
involved in neurogenesis IDA
IDA: Inferred from direct assay
14557550 MGI
involved in neuron projection morphogenesis IDA
IDA: Inferred from direct assay
21483795 MGI
acts upstream of or within non-canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
23677472 MGI
involved in non-canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
15748172 MGI
involved in non-canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20032469 MGI
acts upstream of or within notochord morphogenesis IGI
IGI: Inferred from genetic interaction
25813538 MGI
involved in olfactory bulb interneuron development IMP
IMP: Inferred from mutant phenotype
21539518 MGI
acts upstream of or within paraxial mesoderm formation IGI
IGI: Inferred from genetic interaction
25813538 MGI
acts upstream of or within pericardium morphogenesis IGI
IGI: Inferred from genetic interaction
19795512 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18929644 MGI
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
23109420 MGI
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
20032469 MGI
acts upstream of or within positive regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
19300477 MGI
acts upstream of or within positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
19300477 MGI
involved in positive regulation of apoptotic signaling pathway IDA
IDA: Inferred from direct assay
21857966 MGI
acts upstream of or within positive regulation of cartilage development IDA
IDA: Inferred from direct assay
18991062 MGI
acts upstream of or within positive regulation of cartilage development IMP
IMP: Inferred from mutant phenotype
18991062 MGI
acts upstream of or within positive regulation of cell-cell adhesion mediated by cadherin IDA
IDA: Inferred from direct assay
10893270 MGI
acts upstream of or within positive regulation of cytokine production IDA
IDA: Inferred from direct assay
23677472 MGI
acts upstream of or within positive regulation of endocytosis IDA
IDA: Inferred from direct assay
24305805 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19100728 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21857966 MGI
acts upstream of or within positive regulation of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
9160667 MGI
acts upstream of or within positive regulation of hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
9160667 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
18174455 MGI
involved in positive regulation of interleukin-1 beta production IGI
IGI: Inferred from genetic interaction
21857966 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
21857966 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
18174455 MGI
involved in positive regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
18174455 MGI
acts upstream of or within positive regulation of meiotic nuclear division IGI
IGI: Inferred from genetic interaction
20106871 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
19100728 MGI
involved in positive regulation of neuron projection arborization IGI
IGI: Inferred from genetic interaction
25424568 MGI
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
21539518 MGI
involved in positive regulation of non-canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
23569434 MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
17986005 MGI
acts upstream of or within positive regulation of peptidyl-threonine phosphorylation IGI
IGI: Inferred from genetic interaction
17986005 MGI
involved in positive regulation of protein binding IDA
IDA: Inferred from direct assay
23109420 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15143170 MGI
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15748172 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
19100728 MGI
acts upstream of or within positive regulation of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
18070933 MGI
involved in positive regulation of timing of anagen IDA
IDA: Inferred from direct assay
24681597 MGI
involved in positive regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
21857966 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
21857966 MGI
involved in positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
16601243 MGI
acts upstream of or within post-anal tail morphogenesis IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
19795512 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
28069946 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
28069946 MGI
involved in primary heart field specification IGI
IGI: Inferred from genetic interaction
22569553 MGI
acts upstream of or within primitive streak formation IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
17433286 MGI
acts upstream of or within protein phosphorylation IGI
IGI: Inferred from genetic interaction
17898001 MGI
acts upstream of or within regulation of branching involved in mammary gland duct morphogenesis IDA
IDA: Inferred from direct assay
17898001 MGI
acts upstream of or within regulation of branching involved in mammary gland duct morphogenesis IGI
IGI: Inferred from genetic interaction
17898001 MGI
involved in regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
21857966 MGI
acts upstream of or within regulation of protein localization IDA
IDA: Inferred from direct assay
24305805 MGI
involved in regulation of protein localization IDA
IDA: Inferred from direct assay
17244647 MGI
involved in secondary heart field specification IGI
IGI: Inferred from genetic interaction
22569553 MGI
acts upstream of or within somite development IGI
IGI: Inferred from genetic interaction
25813538 MGI
acts upstream of or within somitogenesis IGI
IGI: Inferred from genetic interaction
19795512 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
19100728 MGI
acts upstream of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
18070933 MGI
acts upstream of or within tube closure IMP
IMP: Inferred from mutant phenotype
19100728 MGI
acts upstream of or within type B pancreatic cell development IMP
IMP: Inferred from mutant phenotype
16246260 MGI
acts upstream of or within urinary bladder development IMP
IMP: Inferred from mutant phenotype
18804104 MGI
acts upstream of or within uterus development IMP
IMP: Inferred from mutant phenotype
15073149 MGI
acts upstream of or within vagina development IMP
IMP: Inferred from mutant phenotype
15073149 MGI
involved in ventricular septum development IGI
IGI: Inferred from genetic interaction
22569553 MGI
Cellular Component GO Annotation Evidence Références Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
28069946 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
28069946 MGI
located in cell surface IDA
IDA: Inferred from direct assay
8167409 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
8167409 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28069946 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28069946 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Wnt-5a

  • wingless-related MMTV integration site 5A

Wnt5a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Wnt5a P22725 Kl Mus musculus O35082
Anti Tag CoIP
17690294
Cross
Wnt5a P22725 WIF1 Homo sapiens Q9Y5W5
Competition Binding
22986341
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P1416A Foxy-5 TFA Agonist 99.17% Phase 2
Inhibitory Antibodies (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P99201 Zilovertamab Inhibitor 98.21% Phase 3

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-123071 Box5 Antagonist 98.81% Unkown
HY-P1416 Foxy-5 Agonist 99.02% Unkown
HY-123071A Box5 TFA Antagonist 99.50% Unkown
HY-12557 γ-Glutamylvaline 99.94% Unkown
HY-116553 FzM1 Inhibitor 98.72% Unkown
HY-N0836 Jervine 99.28% Unkown
HY-RS15837 WNT5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P11867 UM206_L Activator / Unkown
HY-P11867A UM206_C Activator / Unkown
HY-N0836A Jervine hydriodide / Unkown
HY-P5171 MDGCEL Antagonist / Unkown
HY-RS17616 Wnt5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24076 Wnt5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnt5a NCBI NCBI:7474