KDM5A - lysine demethylase 5A Gene

Also Known as RBP2; RBBP2; RBBP-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5927

About KDM5A

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:280,057-389,320 (from NCBI)

This gene has 11 transcripts (splice variants), 211 orthologues, 10 paralogues and is associated with 97 phenotypes. Ubiquitous expression in testis (RPKM 10.6), bone marrow (RPKM 8.6) and 25 other tissues.

Summary

This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) Histone Demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many Other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]

KDM5A Products (1)

mRNA	Protein	Name
NM_001042603.3	NP_001036068.1	lysine-specific demethylase 5A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15640446	GOA
enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity	IDA IDA: Inferred from direct assay	18270511	GOA
enables histone binding	IDA IDA: Inferred from direct assay	19430464	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21960634	GOA
enables transcription cis-regulatory region binding	IMP IMP: Inferred from mutant phenotype	18270511	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19430464	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11358960	GOA
involved in regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18270511	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in nucleus	IDA IDA: Inferred from direct assay	18270511	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM5A Protein Structure

JmjN

ARID

PHD

JmjC

zf-C5HC2

PLU-1

PHD

0
300
600
900
1200
1500
1690 a.a.

Protein Preferred Names	Protein Names
lysine-specific demethylase 5A	Jumonji, AT rich interactive domain 1A (RBP2-like)

KDM5A Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81819	KDM5A Antibody (YA1564)	WB, ICC/IF, IP, FC	Human, Mouse

Related Diseases

Diseases	Alias
Acute Megakaryoblastic Leukemia Without Down Syndrome	Non-Ds-Amkl
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Childhood Acute Myeloid Leukemia	Childhood Acute Myeloid Leukaemia Paediatric Acute Myeloid Leukaemia Pediatric Acute Myeloid Leukemia
Childhood Acute Megakaryoblastic Leukemia	Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia
Syndromic X-Linked Intellectual Disability Claes-Jensen Type	Mental Retardation, X-Linked, Syndromic, Claes-Jensen Type Mrxscj Mrxsj Syndromic X-Linked Intellectual Disability Due To Jarid1c Mutation Syndromic X-Linked Mental Retardation Jarid1c-Related
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Idiopathic Peripheral Autonomic Neuropathy
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-100421	CPI-455	Inhibitor	98.95%	Unkown
HY-147098	dTAG-47	Degrader	99.65%	Unkown
HY-102047B	KDOAM-25 citrate	Inhibitor	98.56%	Unkown
HY-107573	KDM2/7-IN-1	Inhibitor	99.9%	Unkown
HY-100014	KDM5A-IN-1	Inhibitor	99.64%	Unkown
HY-100421A	CPI-455 hydrochloride	Inhibitor	99.95%	Unkown
HY-100624	Ryuvidine	Inhibitor	99.23%	Unkown
HY-119397A	KDM5-C49 hydrochloride	Inhibitor	98.22%	Unkown
HY-158432	GT-653	Degrader	99.84%	Unkown
HY-100764	YUKA1	Inhibitor	99.15%	Unkown
HY-123419	CPI-4203	Inhibitor	99.0%	Unkown
HY-144501	D18		98.79%	Unkown
HY-102047	KDOAM-25	Inhibitor	/	Unkown
HY-119397	KDM5-C49	Inhibitor	/	Unkown
HY-RS07218	KDM5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-102047A	KDOAM-25 trihydrochloride	Inhibitor	/	Unkown
HY-136682	N19-0881	Inhibitor	/	Unkown
HY-RS16664	Kdm5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23099	Kdm5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KDM5A	VGNC	VGNC:30530
Felis catus	KDM5A	VGNC	VGNC:69256
Canis familiaris	KDM5A	VGNC	VGNC:42327
Macaca mulatta	KDM5A	VGNC	VGNC:82169
Mus musculus	KDM5A	MGD	MGI:2136980
Rattus norvegicus	KDM5A	RGD	RGD:1305429
Others	KDM5A	NCBI