TRIP10 - thyroid hormone receptor interactor 10 Gene

Also Known as STP; CIP4; HSTP; STOT; TRIP-10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9322

About TRIP10

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,739,680-6,751,530 (from NCBI)

This gene has 13 transcripts (splice variants), 253 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 54.6), fat (RPKM 34.4) and 22 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in actin Cytoskeleton organization; endocytosis; and signal transduction. Located in nucleoplasm. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Apr 2022]

TRIP10 Products (3)

mRNA	Protein	Name
NM_001288962.2	NP_001275891.1	cdc42-interacting protein 4 isoform 1
NM_001288963.3	NP_001275892.1	cdc42-interacting protein 4 isoform 3
NM_004240.4	NP_004231.1	cdc42-interacting protein 4 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17512409	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16318909	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIP10 Protein Structure

FCH

SH3_1

0
100
200
300
400
500
601 a.a.

Protein Preferred Names	Protein Names
cdc42-interacting protein 4	TR-interacting protein 10

TRIP10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	TRIP10	Q15642	ARHGAP44	Homo sapiens	Q17R89-2	Y2H Array	25416956
Intra	TRIP10	Q15642	ARHGAP44	Homo sapiens	Q17R89-2	Y2H Prey Pooling	25416956
Intra	TRIP10	Q15642	WASF1	Homo sapiens	Q92558	Validated Y2H	25416956
Intra	TRIP10	Q15642	ARHGAP17	Homo sapiens	Q68EM7	Validated Y2H	25416956
Intra	TRIP10	Q15642	SH3BP1	Homo sapiens	Q9Y3L3	Y2H Prey Pooling	25416956
Intra	TRIP10	Q15642	SH3BP1	Homo sapiens	Q9Y3L3	Y2H Array	25416956
Intra	TRIP10	Q15642	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	25416956
Intra	TRIP10	Q15642	SMARCE1	Homo sapiens	Q969G3	Y2H Array	25416956
Intra	TRIP10	Q15642	FASLG	Homo sapiens	P48023	Anti Tag CoIP	16318909
Intra	TRIP10	Q15642	FASLG	Homo sapiens	P48023	Anti Bait CoIP	16318909
Intra	TRIP10	Q15642	FASLG	Homo sapiens	P48023	Pull Down	16318909
Intra	TRIP10	Q15642	RHOJ	Homo sapiens	Q9H4E5	Validated Y2H	25416956
Intra	TRIP10	Q15642	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
Intra	TRIP10	Q15642	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
Intra	TRIP10	Q15642	TRIP10	Homo sapiens	Q15642	Y2H Array	25416956
Intra	TRIP10	Q15642	TRIP10	Homo sapiens	Q15642	X-Ray Diffraction	17512409
Intra	TRIP10	Q15642	TRIP10	Homo sapiens	Q15642	EM	18329367
Intra	TRIP10	Q15642	TRIP10	Homo sapiens	Q15642	Solution Sedimentation	17512409

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TRIP10 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P76260	TRIP10/CIP4 Protein, Human (sf9, His)	NP_004231.1 (M1-N545)	≥ 85%, as determined by reducing SDS-PAGE.

TRIP10 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82758	CIP4 Antibody (YA2503)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Myopathy, Centronuclear, 2	Myopathy, Centronuclear, Autosomal Recessive Autosomal Recessive Centronuclear Myopathy CNM2 Centronuclear Myopathy 2 Ar-Cnm Myotubular Myopathy, Autosomal Recessive Autosomal Recessive Myotubular Myopathy Centronuclear Myopathy Autosomal Recessive Myopathy, Centronuclear, Type 2
Hypochondriasis	Hypochondriacal Disorder Hypochondria Hypochondriacal Neurosis Illness Anxiety Disorder Health Anxiety Disorder Hypochondriacal Reaction
Chronic Recurrent Multifocal Osteomyelitis	Chronic Multifocal Osteomyelitis CRMO Cmo Cno/Crmo Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis Osteomyelitis, Chronic Multifocal Multifocal Osteomyelitis, Chronic Chronic Osteomyelitis Chronic Multifocal Osteomyelitis, Unspecified Site Crmo - [Chronic Multifocal Osteomyelitis] Chronic Osteomyelitis With Draining Sinus, Unspecified Site Bone Fistula With Chronic Osteomyelitis
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15076	TRIP10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRIP10	MGD	MGI:2146901
Canis familiaris	TRIP10	VGNC	VGNC:47844
Macaca mulatta	TRIP10	VGNC	VGNC:78646
Bos taurus	TRIP10	VGNC	VGNC:106998
Rattus norvegicus	TRIP10	RGD	RGD:621145
Felis catus	TRIP10	VGNC	VGNC:66558
Others	TRIP10	NCBI